Dialogue

Peter E Lipsky

doi:10.1038/ncprheum0043 | Full Text | PDF (50K)

Challenges of predicting treatment response in patients with rheumatoid arthritis

Josef S Smolen and Daniel Aletaha

Choosing the correct management strategy for patients with rheumatoid arthritis in order to achieve the best possible outcome is a challenge to all rheumatologists. This Viewpoint considers current progress in the field of outcomes research in rheumatoid arthritis, along with future prospects of predicting individual patient response to therapy.

doi:10.1038/ncprheum0050 | Full Text | PDF (72K)

In-office imaging in the care of patients with rheumatoid arthritis

John T Sharp

The standards of 'state of the art' in-office imaging are rapidly changing. This Viewpoint assesses the imaging techniques available for in-office use and highlights the obstacles that need to be overcome in this field in order for clinicians to have easy access to the right data in order to provide the best possible care.

doi:10.1038/ncprheum0051 | Full Text | PDF (77K)

Long-term outcome of multiple arthroplasty in patients with rheumatoid arthritis

Rachel Murphy

doi:10.1038/ncprheum0021 | Full Text | PDF (73K)

Long-term use of aspirin and NSAIDs reduces the risk of colorectal cancer

Rachel Murphy

doi:10.1038/ncprheum0022 | Full Text | PDF (64K)

Extra-virgin olive oil has similar activity to ibuprofen

Rachel Murphy

doi:10.1038/ncprheum0023 | Full Text | PDF (64K)

Urine-based polymerase chain reaction is not suitable for diagnosing Lyme borreliosis

Rachel Murphy

doi:10.1038/ncprheum0024 | Full Text | PDF (65K)

Recombinant osteoprotegerin suppresses bone resorption in juvenile Paget's disease

Rachel Murphy

doi:10.1038/ncprheum0025 | Full Text | PDF (73K)

GnRH analogue protects against cyclophosphamide-induced ovarian failure in SLE

Rachel Murphy

doi:10.1038/ncprheum0026 | Full Text | PDF (95K)

Rituximab is an effective treatment for Sjögren's syndrome

Rebecca Doherty

doi:10.1038/ncprheum0027 | Full Text | PDF (73K)

A sensitive marker of pulmonary fibrosis activity in systemic sclerosis

Carol Lovegrove

doi:10.1038/ncprheum0028 | Full Text | PDF (65K)

A role for genotype in predicting efficacy and toxicity of methotrexate?

Carol Lovegrove

doi:10.1038/ncprheum0029 | Full Text | PDF (64K)

A new instrument for assessing dactylitis in psoriatic arthritis

Ruth Kirby

doi:10.1038/ncprheum0030 | Full Text | PDF (73K)

Improved outcome in acute or subacute interstitial pneumonia using combination therapy

Carol Lovegrove

doi:10.1038/ncprheum0031 | Full Text | PDF (78K)

Cytokine genotype relates to outcome in juvenile rheumatoid arthritis

Carol Lovegrove

doi:10.1038/ncprheum0032 | Full Text | PDF (73K)

Low-field dedicated-extremity MRI in rheumatoid arthritis

Carol Lovegrove

doi:10.1038/ncprheum0033 | Full Text | PDF (65K)

Nifedipine improves myocardial perfusion and function in systemic sclerosis

Carol Lovegrove

doi:10.1038/ncprheum0034 | Full Text | PDF (64K)

Does hormone replacement therapy affect disease activity in patients with systemic lupus erythematosus?

Rosalind Ramsey-Goldman

doi:10.1038/ncprheum0045 | Full Text | PDF (72K)

Do tumor-necrosis-factor inhibitors prevent first cardiovascular events in patients with rheumatoid arthritis?

Mariana J Kaplan

doi:10.1038/ncprheum0066 | Full Text | PDF (77K)

Does acupuncture help reduce pain in patients with fibromyalgia?

Daniel J Clauw

doi:10.1038/ncprheum0065 | Full Text | PDF (74K)

A new scoring system for Sjögren's syndrome?

Roland Jonsson

doi:10.1038/ncprheum0068 | Full Text | PDF (76K)

Is tacrolimus effective for treating antisynthetase-associated interstitial lung disease?

Tim Bongartz, Jay H Ryu and Eric L Matteson

doi:10.1038/ncprheum0067 | Full Text | PDF (75K)

The management of pediatric systemic lupus erythematosus

Stacy P Ardoin and Laura E Schanberg

The improved prognosis of children with systemic lupus erythematosus over the past 50 years means that rheumatologists now focus on preventing the long-term complications associated with this disease and its treatment. As discussed in this review, a specialized multidisciplinary approach is needed to ensure optimum family education, treatment and patient outcome in pediatric systemic lupus erythematosus.

doi:10.1038/ncprheum0046 | Full Text | PDF (272K)

Drug Insight: endothelin-receptor antagonists for pulmonary arterial hypertension in systemic rheumatic diseases

Marc Humbert and Gérald Simonneau

Pulmonary arterial hypertension is particularly common in individuals with systemic sclerosis, but is also seen in other rheumatic diseases. A number of treatment optionsfor this serious complication are available, including selective and unselective endothelin-receptor antagonists, which are the subject of this review.

doi:10.1038/ncprheum0048 | Full Text | PDF (205K)

Mechanisms of Disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis

Ulf Müller-Ladner, Thomas Pap, Renate E Gay, Michel Neidhart and Steffen Gay

Molecular biology techniques have enabled the pathophysiologic pathways involved in joint destruction in rheumatoid arthritis to be elucidated at the cellular and molecular level. In this review, the authors discuss the various cell-to-cell and cell-to-matrix interactions, highlighting the role of cytokine-independent pathways and the innate immune system in these processes.

doi:10.1038/ncprheum0047 | Full Text | PDF (324K)