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Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis

Latest Reviews

  • Review |

    This article provides an overview of the pathophysiology of enthesitis, from induction and inflammation to tissue proliferation and bone formation. Building on these pathophysiological concepts, the clinical presentation, assessment and treatment of enthesitis are also discussed.

    • Georg Schett
    • , Rik J. Lories
    • , Maria-Antonietta D'Agostino
    • , Dirk Elewaut
    • , Bruce Kirkham
    • , Enrique R. Soriano
    •  & Dennis McGonagle
  • Review |

    The symptomatic pre-arthritis phase of rheumatoid arthritis (RA) is hypothesized to be part of a 'window of opportunity' for preventive treatment. This Review discusses the methodological considerations when designing and interpreting preventive trials, and translating findings into clinical practice.

    • Hanna W. van Steenbergen
    • , José A. Pereira da Silva
    • , Tom W. J. Huizinga
    •  & Annette H. M. van der Helm-van Mil
  • Review |

    In the past few years, excitement has grown over the potential use of mesenchymal stem cells (MSCs) for cartilage repair, although the rarity of these cells has hampered progress. In this Review, the authors examine the potential of joint-resident MSCs as a new avenue for repair in osteoarthritis.

    • Dennis McGonagle
    • , Thomas G. Baboolal
    •  & Elena Jones
  • Perspective |

    Symptoms associated with chronic inflammatory diseases such as fatigue, depression and muscle loss are often overlooked during treatment. This Perspectives article provides a framework for understanding many of these symptoms that is based on the concepts of evolutionary medicine, energy regulation and neuroendocrine–immune crosstalk.

    • Rainer H. Straub
  • Review |

    In this Review, the role of canonical Wnt signalling in articular cartilage is discussed, along with the regulatory mechanisms that exist to fine-tune Wnt signalling and the rationale for developing drugs that modulate Wnt signalling for the treatment of joint diseases such as osteoarthritis.

    • Silvia Monteagudo
    •  & Rik J. Lories

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