Top 10
The top ten charts the articles that have been downloaded most often, in HTML format, from the Nature Reviews Neurology website in recent weeks. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.
Top of pageResearch Highlight
Parkinson disease: Propagation of disease pathology in PD
Darran Yates
doi:10.1038/nrneurol.2009.142
Research Highlight
Spinal cord injury: Plasticity provides an opportunity for rehabilitation
Nick Jones
doi:10.1038/nrneurol.2009.140
Research Highlight
Research Highlight
Case Study
Harlequin syndrome - one face of many etiologies
Gunnar Wasner, Rainer Maag, Janne Ludwig, Andreas Binder, Jörn Schattschneider, Robert Stingele & Ralf Baron
doi:10.1038/ncpneuro0040
News and Views
Neurodegenerative disease: Genetic discrimination in Huntington disease
Stefan M. Pulst
doi:10.1038/nrneurol.2009.153
Case Study
A case of neuropathic brachioradial pruritus caused by cervical disc herniation
Andreas Binder, Regina Fölster-Holst, Gülcan Sahan, Jana Koroschetz, Maike Stengel, H Maximilian Mehdorn, Thomas Schwarz & Ralf Baron
doi:10.1038/ncpneuro0807
This Case Study describes a 64-year-old woman who presented with a 2-year history of itch on her right dorsal forearm. The patient was diagnosed with brachioradial pruritus caused by cervical disc herniation, and the symptoms resolved after surgery to decompress the sixth cervical nerve root. Various alternative treatment options for brachioradial pruritus are discussed.
Review
Neurological complications of chronic kidney disease
Arun V. Krishnan & Matthew C. Kiernan
doi:10.1038/nrneurol.2009.138
Chronic kidney disease is a serious global health problem, and almost all patients with severe forms of the disease develop neurological complications, which can include cognitive impairment, cerebrovascular disease and peripheral neuropathies. Krishnan and Kiernan review the clinical features and pathophysiology of the most common neurological complications of chronic kidney disease, and highlight the currently available treatment options.
Research Highlight
Neuro-Oncology: Talampanel enhances survival in glioblastoma
Kathryn Senior
doi:10.1038/nrneurol.2009.147
Review
Lumbar spinal stenosis: syndrome, diagnostics and treatment
Eberhard Siebert, Harald Prüss, Randolf Klingebiel, Vieri Failli, Karl M. Einhäupl & Jan M. Schwab
doi:10.1038/nrneurol.2009.90
In lumbar spinal stenosis (LSS), narrowing of the spinal canal leads to neural compression and, frequently, pain in the lower back. LSS has become the most common reason for lumbar spine surgery, partly reflecting the elevated demand for mobility and flexibility in the aging population. In this article, Siebert et al. review the underlying pathophysiology of LSS, and discuss how to diagnose and treat the condition.
