The introduction of recombinant tissue-type plasminogen activator (tPA) revolutionized stroke treatment, but experimental studies have suggested potential toxic effects of this molecule on various components of the CNS. Two new studies have added further insight into the complex CNS effects of tPA following traumatic brain injury and brain ischaemia.
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Vivien, D., Ali, C. Tissue-type plasminogen activator—harmful or beneficial?. Nat Rev Neurol 8, 538–539 (2012). https://doi.org/10.1038/nrneurol.2012.192
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DOI: https://doi.org/10.1038/nrneurol.2012.192
