Observational studies suggest that high homocysteine levels are a risk factor for brain atrophy and Alzheimer disease, but intervention studies have been inconclusive. New evidence that B vitamin therapy can slow brain atrophy will allow re-examination of elevated homocysteine levels as a potentially treatable risk factor for this disease.
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Sachdev, P. Homocysteine and Alzheimer disease: an intervention study. Nat Rev Neurol 7, 9–10 (2011). https://doi.org/10.1038/nrneurol.2010.195
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DOI: https://doi.org/10.1038/nrneurol.2010.195
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