Evidence suggests that both anxiety and depression might have pathophysiological links with Parkinson disease (PD), as these mood disorders are more prevalent in individuals with PD than in patients with other chronic conditions. A new study reports that depression and anxiety are associated with different patterns of PD-related factors, suggesting divergence between the underlying mechanisms.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy
Translational Psychiatry Open Access 24 February 2022
-
Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice
Molecular Brain Open Access 01 December 2020
-
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment
Molecular Psychiatry Open Access 14 March 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pontone, G. M. et al. Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease. Mov. Disord. 24, 1333–1338 (2009).
Aarsland, D., Marsh, L. & Schrag, A. Neuropsychiatric symptoms in Parkinson's disease. Mov. Disord. 24, 2175–2186 (2009).
Beekman, A. T., Copeland, J. R. & Prince, M. J. Review of community prevalence of depression in later life. Br. J. Psychiatry 174, 307–311 (1999).
Bryant, C., Jackson, H. & Ames, D. The prevalence of anxiety in older adults: methodological issues and a review of the literature. J. Affect. Disord. 109, 233–250 (2008).
Nègre-Pagès, L. et al. Anxious and depressive symptoms in Parkinson's disease: the French cross-sectional DoPaMiP study. Mov. Disord. 25, 157–166 (2009).
Schrag, A. et al. Depression rating scales in Parkinson's disease: critique and recommendations. Mov. Disord. 22, 1077–1092 (2007).
Leentjens, A. F. et al. Anxiety rating scales in Parkinson's disease: critique and recommendations. Mov. Disord. 23, 2015–2025 (2008).
Marsh, L., McDonald, W. M., Cummings, J. & Ravina, B. Provisional diagnostic criteria for depression in Parkinson's disease: report of an NINDS/NIMH Work Group. Mov. Disord. 21, 148–158 (2006).
Alonso, A., Rodríguez, L. A., Logroscino, G. & Hernán, M. A. Use of antidepressants and the risk of Parkinson's disease: a prospective study. J. Neurol. Neurosurg. Psychiatry 80, 671–674 (2009).
Rodriguez-Oroz, M. C. et al. Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms. Lancet Neurol. 8, 1128–1139 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Martínez-Martín, P., Damián, J. Depression and anxiety in Parkinson disease. Nat Rev Neurol 6, 243–245 (2010). https://doi.org/10.1038/nrneurol.2010.49
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2010.49
This article is cited by
-
Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy
Translational Psychiatry (2022)
-
Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice
Molecular Brain (2020)
-
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment
Molecular Psychiatry (2017)
-
Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease
Journal of Neurology (2012)
