Table of contents
November 2008 Volume 4 No 11
Editorial
Research Highlights
A potential new drug target for the treatment of schizophrenia
580doi:10.1038/ncpneuro0903 | Full Text | PDF (100K)
Fatty acids do not reduce cognitive decline but might protect against stroke
580Response to antidepressants is linked to TrkB signaling in forebrain progenitor neurons
581Is antifibrinolytic therapy beneficial after aneurysmal subarachnoid hemorrhage?
581doi:10.1038/ncpneuro0906 | Full Text | PDF (126K)
Stimulation of the subthalamic nucleus targets specific motor symptoms in Parkinson disease
582doi:10.1038/ncpneuro0907 | Full Text | PDF (116K)
Generation of motor neurons from skin fibroblasts of a patient with ALS
582Amyloid load has a role in dementia with Lewy bodies
583AMPA receptor endocytosis is a potential target in heroin addiction
583Practice Points
Pitfalls of diagnostic criteria for small fiber neuropathy
586doi:10.1038/ncpneuro0920 | Full Text | PDF (163K)
How effective is intravenous immunoglobulin for the treatment of relapsing–remitting multiple sclerosis?
588doi:10.1038/ncpneuro0923 | Full Text | PDF (163K)
Long-term outcome in Parkinson disease: no advantage to initiating therapy with dopamine agonists
590doi:10.1038/ncpneuro0934 | Full Text | PDF (157K)
The Boston Acute Stroke Imaging Scale: ready for use in clinical practice?
592doi:10.1038/ncpneuro0919 | Full Text | PDF (159K)
Duloxetine and pregabalin: safe and effective for the long-term treatment of fibromyalgia?
594doi:10.1038/ncpneuro0936 | Full Text | PDF (165K)
Red flags to spot the parkinsonian variant of multiple system atrophy
596doi:10.1038/ncpneuro0881 | Full Text | PDF (158K)
Viewpoint
Withdrawal of antiepileptic drugs in seizure-free patients: chance or jeopardy?
598The decision whether to withdraw antiepileptic drugs in adults who have been seizure-free for 2 years is a difficult one, with relief from adverse events weighing against the possibility of seizure recurrence with all its consequences. In this Viewpoint, Alla Guekht calls on clinicians not to dismiss lightly the risk of relapse.
doi:10.1038/ncpneuro0937 | Full Text | PDF (166K)
Reviews
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
600Mitochondrial dysfunction and oxidative stress have been strongly implicated in the pathogenesis of Parkinson disease (PD), and the products of several PD-associated genes become localized to the mitochondria under certain conditions. In this article, Henchcliffe and Beal review recent developments in mitochondrial biology that have contributed to our understanding of the disease process in PD, and they discuss how this knowledge might aid in the development of 'mitochondrial therapies' for PD.
doi:10.1038/ncpneuro0924 | Full Text | PDF (413K)
The mortality and morbidity of febrile seizures
610Therapeutic approaches to febrile seizures have changed since the 1970s when the main reference studies on this topic were published. It is, therefore, timely to consider whether outcomes of febrile seizures have changed in the intervening years. Here, Chungath and Shorvon assess data published since 1993 with respect to three outcomes: mortality, later development of afebrile seizures or epilepsy, and hippocampal or mesial temporal sclerosis.
doi:10.1038/ncpneuro0922 | Full Text | PDF (381K)
Case Studies
A case of cocaine-induced basilar artery thrombosis
622This article discusses the case of a 40-year-old man with basilar artery thrombosis, which, after numerous investigations, was found to be attributable to cocaine use. The authors highlight the importance of asking patients about cocaine exposure as part of a routine cardiovascular history, and they provide the first description of the use of thrombolysis to treat cocaine-induced stroke.
doi:10.1038/ncpneuro0879 | Full Text | PDF (325K)
BOLD-MRI cerebrovascular reactivity findings in cocaine-induced cerebral vasculitis
628This Case Study describes an 18-year-old woman who presented to a stroke center with dysphasia and right hemiparesis. The patient was diagnosed with cocaine-induced cerebral vasculitis. BOLD MRI cerebrovascular reactivity findings were particularly useful in the diagnosis and follow-up of this case, and the authors point to the technique's potential for imaging cerebral vasculitis in general.
doi:10.1038/ncpneuro0918 | Full Text | PDF (582K)
Training Matters
The new pain curriculum: a guide for neurologists who teach
634Pain is a leading reason for seeking medical care, but the management of pain is often felt to be inadequate. A good place to start tackling this problem is in the training of future doctors. This Training Matters article provides excellent advice for neurologists who are involved in the teaching of pain and its management.
doi:10.1038/ncpneuro0902 | Full Text | PDF (164K)
