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Research Highlights
Nature Reviews Neurology 2, 643 (1 December 2006) | doi:10.1038/ncpneuro0335
Activation of the TRPM8 channel can generate analgesia in chronic neuropathic pain
Abstract
Proudfoot CJ et al. (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16: 1591–1605 Peripheral or central activation of the TRPM8 (transient receptor potential melastatine family member 8) cool-sensitive ion channel can produce an analgesic effect, reversing hypersensitivity and reducing chronic neuropathic pain resulting from peripheral nerve damage, reports a paper in Current Biology.
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