Table of contents
December 2006 Volume 2 No 12
Editorial
Viewpoint
Research Highlights
Cerebral artery thrombi show similar structural composition regardless of etiology
640Argatroban could improve recanalization in stroke patients
640High-dose cyclophosphamide can effectively treat severe refractory multiple sclerosis
640Topiramate has high efficacy and tolerability in treating chronic tension-type headache
641Quantification of glycosyltransferase mRNA in GBM has prognostic value
641A molecular biomarker for the diagnosis of Alzheimer's disease
642Endocannabinoids target glutamatergic neurons to protect against seizures
642Activation of the TRPM8 channel can generate analgesia in chronic neuropathic pain
643Developmental abnormalities in the brains of patients with Prader–Willi syndrome
643Atypical antipsychotics reduce prepulse inhibition deficits associated with schizophrenia
643Large study finds association between SNCA promoter variability and PD
644Early treatment of schizophrenia normalizes metabolic profile
644Multiple acute ischemic lesion pattern can occur in stroke with no embolic source
645Practice Points
Secondary prevention measures after a stroke—should they target stroke or heart disease?
646Can amantadine therapy delay the onset of dementia in Parkinson's disease?
648Skin biopsy findings predict development of symptomatic neuropathy in patients with HIV
650Management of bladder dysfunction in patients with multiple-system atrophy
652Can medication overuse headache be treated by abrupt withdrawal of the overused agent?
654Reviews
Are frontotemporal lobar degeneration, progressive supranuclear palsy and corticobasal degeneration distinct diseases?
658Historically, frontotemporal lobar degeneration, corticobasal degeneration and progressive supranuclear palsy have been classified as separate disorders on the basis of distinctive clinical and pathological features. Recent studies using modern molecular and genetic approaches, however, have raised awareness of similarities between these conditions. In this Review, the authors discuss the similarities and differences between these three disorders, and present an argument for their continued separation.
doi:10.1038/ncpneuro0357 | Full Text | PDF (206K)
Essential tremor: emerging views of a common disorder
666In this Review, Julián Benito-León and Elan Louis discuss the epidemiology, pathophysiology, diagnosis and treatment of essential tremor, one of the most common neurological disorders in adults. This condition has traditionally been viewed as a monosymptomatic disorder characterized by a kinetic arm tremor, but the clinical spectrum is now expanding to include other motor and non-motor features.
doi:10.1038/ncpneuro0347 | Full Text | PDF (880K)
Mechanisms of Disease: astrocytes in neurodegenerative disease
679Investigations into the mechanisms underlying neurodegenerative disease have tended to focus largely on neuronal abnormalities, but it is becoming increasingly evident that astrocytes are important players in these and other neurological disorders. In this Review, the authors describe the normal roles of astrocytes in the brain, and discuss how animal models have provided important insights into the consequences of astrocyte dysfunction.
doi:10.1038/ncpneuro0355 | Full Text | PDF (276K)
Training Matters
How to bring neurology and psychiatry closer? Trainees, trainers and teachers support shared learning
690In this Training Matters article, the authors promote the case for increased integration of neurology and psychiatry training, which they suggest will lead ultimately to improved patient care.
