High levels of adiposity are associated with poor clinical outcomes in patients with demyelination, a new study has shown. For 5 years, investigators studied 279 patients with a first diagnosis of CNS demyelination, and found that patients with a high BMI, large hip circumference and high levels of triglycerides were more likely to relapse. In addition, the total cholesterol:HDL ratio and levels of adiposity and non-HDL cholesterol correlated with an increased rate of disability, indicating that improvement of lipid profile could reduce the risk of disability after a demyelinating event.
References
Tettey, P. et al. An adverse lipid profile and increased levels of adiposity significantly predict clinical course after a first demyelinating event. J. Neurol. Neurosurg. Psychiatry http://dx.doi.org/10.1136/jnnp-2016-315037 (2017)
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Ridler, C. Adiposity is associated with increased disability rates after a demyelinating event. Nat Rev Neurol 13, 258 (2017). https://doi.org/10.1038/nrneurol.2017.52
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DOI: https://doi.org/10.1038/nrneurol.2017.52
