Paediatric low-grade gliomas have a good prognosis; however, a recent follow-up study of 1,202 children reports that survivors of childhood low-grade glioma are at increased risk of late mortality. Most of the deaths recorded at follow-up (median 13 years) were linked to tumour transformation or non-oncological causes rather than tumour progression. Radiotherapy was the most important risk factor for late all-cause deaths.
References
Krishnatry, R. et al. Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: a population-based study. Cancer http://dx.doi.org/10.1002/cncr.29907 (2016)
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Malkki, H. Long-term outcomes in childhood low-grade glioma. Nat Rev Neurol 12, 188 (2016). https://doi.org/10.1038/nrneurol.2016.42
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DOI: https://doi.org/10.1038/nrneurol.2016.42