Sports-related concussion alters the balance of neuroactive kynurenine pathway metabolites and consequently affects mood, a recent study shows. Athletes with concussion exhibited abnormally high levels of quinolinic acid and low kynurenine acid–quinolinic acid ratios. A 1-month follow-up indicated no normalization, and the low ratio was associated with depressive symptoms and a tendency for anxiety.
References
Singh, R. et al. Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion. Neuropsychiatry 10.1136/jnnp-2015-311369
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Metabolites link concussion and mood. Nat Rev Neurol 11, 547 (2015). https://doi.org/10.1038/nrneurol.2015.165
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DOI: https://doi.org/10.1038/nrneurol.2015.165