Nicholas R. Evans/Caio Bracey

Free Article Series: Peripheral Neuropathies

Latest Reviews

  • Review |

    Inadequate remyelination is central to degeneration and disability in patients with multiple sclerosis (MS); however, all currently approved therapies for MS are primarily immunomodulatory. Here, Martin Stangel and colleagues review our current knowledge of remyelination in MS, discuss results from clinical trials of remyelination-enhancing therapies, and evaluate the opportunities for future regenerative treatments.

    • Martin Stangel
    • , Tanja Kuhlmann
    • , Paul M. Matthews
    •  & Trevor J. Kilpatrick
  • Review |

    The causes of migraine remain unknown despite the high prevalence and societal burden of this disorder. Here, the authors highlight how advances in imaging and genetic studies of migraine provide insights into the underlying mechanisms of this disorder; furthermore, they discuss the potential for genetic and imaging biomarkers to improve our ability to prevent and treat migraine attacks.

    • Dale R. Nyholt
    • , David Borsook
    •  & Lyn R. Griffiths
  • Opinion |

    The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer immunotherapy, but these agents carry a high risk of immune-related adverse events. Here, the authors introduce the mechanisms of action of ICIs and review their adverse effects on the CNS, which result in conditions such as paraneoplastic neurological syndromes and multiple sclerosis.

    • Lidia M. Yshii
    • , Reinhard Hohlfeld
    •  & Roland S. Liblau
  • Opinion |

    Sadnicka and colleagues present task-specific dystonia in the context of motor skill learning in health. Their framework integrates established risk factors for task-specific dystonia with mechanisms of motor skill learning, to indicate how disrupted neural representations of motor skills might arise.

    • Anna Sadnicka
    • , Katja Kornysheva
    • , John C. Rothwell
    •  & Mark J. Edwards
  • Review |

    Exercise and physical therapy are important adjunct interventions to improve gait and balance impairments in patients with Parkinson disease (PD), as these features are inadequately treated by current pharmacological and surgical treatments. Here, Mak and colleagues discuss the long-term effects of exercise and physical therapy for PD, possible risks, recommendations for clinical practice, and emerging treatment approaches.

    • Margaret K. Mak
    • , Irene S. Wong-Yu
    • , Xia Shen
    •  & Chloe L. Chung
  • Review |

    Fatigue, defined as extreme and persistent mental and/or physical tiredness, weakness or exhaustion, frequently occurs as a challenging symptom or comorbidity in many neurological diseases. In this Review, Penner and Paul discuss the definitions and manifestations of fatigue, focusing on its pathophysiological background, assessment strategies, and current treatment options.

    • Iris-Katharina Penner
    •  & Friedemann Paul

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