Top 10
The top ten charts the articles that have been downloaded most often, in HTML format, from the Nature Reviews Nephrology website in recent weeks. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.
Top of pageResearch Highlight
Prevention: Lifestyle affects risk of hypertension and kidney stones
Susan J. Allison
doi:10.1038/nrneph.2009.160
Research Highlight
Biomarkers: Rapid urine test for kidney disease
Lisa Richards
doi:10.1038/nrneph.2009.121
News and Views
Glomerular disease: The Oxford classification—predicting progression of IgAN
Frank Eitner & Jürgen Floege
doi:10.1038/nrneph.2009.150
Research Highlight
Acute kidney injury: uNGAL—a marker of moderate utility in critically ill adults
Baldo Lucchese
doi:10.1038/nrneph.2009.158
Review
Orthostatic hypertension: when pressor reflexes overcompensate
Joshua Fessel & David Robertson
doi:10.1038/ncpneph0228
Authors from the Autonomic Dysfunction Center at Vanderbilt University present an overview of what is known about this poorly understood and often overlooked form of blood pressure dysregulation. The definition, pathophysiology, diagnosis and treatment of orthostatic hypertension, and conditions associated with it, are touched on. Through their comprehensive analysis, Fessel and Robertson detect the gaps in knowledge that should direct future research.
News and Views
Proteinuria: Is the ONTARGET renal substudy actually off target?
Piero Ruggenenti & Giuseppe Remuzzi
doi:10.1038/nrneph.2009.109
Review
Urinary tract infection in the renal transplant patient
Ruth M de Souza & Jonathon Olsburgh
doi:10.1038/ncpneph0781
Since the first successful kidney transplantations were performed in the 1950s, understanding of the factors that improve graft outcome has advanced. Nevertheless, post-transplantation urinary tract infections continue to be a source of morbidity and graft failure. This article reviews urinary tract infection in the renal transplant recipient, covering epidemiology, etiology, prevention, presentation, investigations, diagnosis and management.
News and Views
Transplantation: Time to rethink immunosuppression by mTOR inhibitors?
Marcus D. Säemann & Giuseppe Remuzzi
doi:10.1038/nrneph.2009.168
Research Highlight
Review
Skin problems in chronic kidney disease
Dirk RJ Kuypers
doi:10.1038/ncpneph1040
Skin disorders are very common in patients with chronic kidney disease and can seriously affect their mental and physical health. Although the majority of the disorders are relatively benign, some can cause serious morbidity and mortality. Early recognition of these severe skin disorders and prompt initiation of treatment can dramatically alter their course and even save a patient's life. This Review discusses characteristics, pathophysiology and treatment of uremic pruritus, calcific uremic arteriolopathy and nephrogenic systemic fibrosis, and briefly describes acquired perforating dermatosis (Kyrle disease) and porphyria cutanea tarda.
