FIGURE 3 | Role of polycystins in left–right asymmetry.

From the following article:

Polycystins and renovascular mechanosensory transduction

Amanda Patel & Eric Honoré

Nature Reviews Nephrology 6, 530-538 (September 2010)


Polycystins and renovascular mechanosensory transduction

a | Normal left–right asymmetry (situs solitus) and situs inversus as is observed in Pkd2-knockout mice. b | Motile cilia in the center of the embryonic node generate a leftward nodal flow that induces bending of non-motile sensory primary cilia at the periphery of the node and triggers an asymmetric calcium distribution in the node. The bending of these cilia is thought to induce opening of polycystin-2, calcium influx, and an increase in the intracellular calcium concentration that initiates the development of left–right asymmetry. However, other signal transduction events including the ligand stimulation of membrane receptors are also likely to have a role. Permission obtained from Nature Publishing Group © Fliegauf, M. et al. Nat. Rev. Mol. Cell Biol. 8, 880–893 (2007).

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