Changes in serum creatinine concentration are used to define acute kidney injury after the intravascular administration of iodinated contrast media, but less is known about the short-term increases in levels of cystatin C after angiography. A new study investigates whether cystatin C is a reliable marker of contrast-induced acute kidney injury after angiography.
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References
Rudnick, M. R., Berns, J. S., Cohen, R. M. & Goldfarb, S. Contrast media-associated nephrotoxicity. Semin. Nephrol. 17, 15–26 (1997).
McCullough, P. A. Contrast-induced acute kidney injury. J. Am. Coll. Cardiol. 51, 1419–1428 (2008).
Reddan, D., Laville, M. & Garovic, V. D. Contrast-induced nephropathy and its prevention: what do we really know from evidence-based findings? J. Nephrol. 22, 333–351 (2009).
Mehran, R. & Nikolsky, E. Contrast-induced nephropathy: definition, epidemiology, and patients at risk. Kidney Int. Suppl. S11–S15 (2006).
Levy, E. M., Viscoli, C. M. & Horwitz, R. I. The effect of acute renal failure on mortality. A cohort analysis. JAMA 275, 1489–1494 (1996).
McCullough, P. A., Wolyn, R., Rocher, L. L., Levin, R. N. & O'Neill, W. W. Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality. Am. J. Med. 103, 368–375 (1997).
Rihal, C. S. et al. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation 105, 2259–2264 (2002).
McCullough, P. A. et al. Epidemiology and prognostic implications of contrast-induced nephropathy. Am. J. Cardiol. 98, 5K–13K (2006).
Briguori, C. et al. Cystatin C and contrast-induced acute kidney injury. Circulation 121, 2117–2122 (2010).
Newman, D. J. et al. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int. 47, 312–318 (1995).
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Weisbord, S., Palevsky, P. Kidney injury after contrast media: marker or mediator?. Nat Rev Nephrol 6, 634–636 (2010). https://doi.org/10.1038/nrneph.2010.129
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DOI: https://doi.org/10.1038/nrneph.2010.129