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Vasculitis syndromes

LAMP-2 illuminates pathogenesis of ANCA glomerulonephritis

Nature Reviews Nephrology volume 5, pages 247–249 (2009)Cite this article

The discovery that antibodies to a bacterial antigen can cross-react with a mammalian protein to cause pauci-immune necrotizing and crescentic glomerulonephritis opens up new possibilities for the diagnosis and treatment of this condition.

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Figure 1: Renal biopsy specimen showing focal necrotizing glomerulonephritis in a patient with antineutrophil cytoplasmic antibody (ANCA)-associated microscopic polyangiitis.

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Authors and Affiliations

  1. Department of Internal Medicine, Hospital Clinic, Institut d'Investigació Biomédica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

    Xavier Bosch

  2. Department of Nephrology, Hospital Clinic, Institut d'Investigació Biomédica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

    Eduard Mirapeix

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  1. Xavier Bosch
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  2. Eduard Mirapeix
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Correspondence to Xavier Bosch.

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Bosch, X., Mirapeix, E. LAMP-2 illuminates pathogenesis of ANCA glomerulonephritis. Nat Rev Nephrol 5, 247–249 (2009). https://doi.org/10.1038/nrneph.2009.51

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