Table of contents
August 2008 Volume 4 No 8
Editorial
The unique role of nephrologists in the pursuit of global health goals
405doi:10.1038/ncpneph0893 | Full Text | PDF (100K)
Research Highlights
Point-of-care measurement device can accurately identify patients with microalbuminuria
406Loop diuretic use increases bone loss in older men
406Serum cystatin C versus serum creatinine for GFR estimation in patients with HIV
406AKIN modifications do not improve the RIFLE criteria for acute kidney injury
407Self-measured blood pressure for the titration of antihypertensive medication
407Use of accelerated venovenous hemofiltration in the intensive care setting
408Pentoxifylline lowers proteinuria in patients with diabetic nephropathy
408CKD increases risk of acute kidney injury during hospitalization
408Risk of death versus end-stage renal disease in patients with CKD without diabetes
409Hypertensive CKD in African Americans progresses despite treatment
409No need to screen kidney donors or recipients for Toxoplasma where seroprevalence is low
410Potential kidney donors accept higher donor risk than do clinicians or recipients
410Ureteral stent placement during kidney transplantation confers no benefit in children
411Practice Points
Does intensive insulin therapy protect renal function in critically ill patients?
412doi:10.1038/ncpneph0855 | Full Text | PDF (121K)
Assessment of urinary albumin excretion might improve cardiovascular outcome in patients with hypertension
414doi:10.1038/ncpneph0861 | Full Text | PDF (126K)
Is calcitriol treatment associated with improved survival in predialysis patients with chronic kidney disease?
416doi:10.1038/ncpneph0857 | Full Text | PDF (124K)
Does ferric gluconate lower epoetin requirements in hemodialysis patients with high ferritin levels?
418doi:10.1038/ncpneph0858 | Full Text | PDF (124K)
Viewpoints
Routine reporting of estimated glomerular filtration rate: not ready for prime time
422According to the Kidney Disease Outcomes Quality Initiative guidelines, estimated glomerular filtration rate can be used to diagnose chronic kidney disease. The authors of this Viewpoint argue, however, that reliance on estimated glomerular filtration rates alone encourages an erroneous disregard of age, gender and other evidence of kidney disease, such as proteinuria. Consequently, mandatory reporting of estimated glomerular filtration rate leads to misdiagnosis of chronic kidney disease and to the unhelpful referral of healthy individuals to nephrologists.
doi:10.1038/ncpneph0860 | Full Text | PDF (129K)
Does hyperlipidemia injure the kidney?
424A relationship between disturbed lipid metabolism and kidney disease was first postulated in 1858. Over the years, many animal studies have indicated that lipids have a pathophysiologic role in renal disease. The authors of this Viewpoint describe the possible mechanisms through which lipids might promote the progression of glomerular and tubulointerstitial diseases.
doi:10.1038/ncpneph0863 | Full Text | PDF (126K)
Reviews
An overview of nocturia and the syndrome of nocturnal polyuria in the elderly
426This Review provides an overview of nocturia in the elderly for the practicing nephrologist. The authors attempt to correct the misconception that nocturia is usually caused by urologic problems, arguing that, in fact, nocturia in the elderly results from the interacting effects of aging and sleep on renal and urinary function. Specific causes of this condition, including the syndrome of nocturnal polyuria, are discussed, and the best strategies for evaluation and treatment—both pharmacologic and non-pharmacologic—are summarized.
doi:10.1038/ncpneph0856 | Full Text | PDF (233K)
Anemia and anemia correction: surrogate markers or causes of morbidity in chronic kidney disease?
436In this Review, Nosratola Vaziri endeavors to reconcile two apparently conflicting sets of evidence from patients with chronic kidney disease: the observational association between greater severity of anemia and increased risk of poor outcomes, and the increased risk of adverse outcomes in patients assigned to normal, rather than subnormal, hemoglobin targets in randomized clinical trials. The author focuses on data from basic and translational studies, which are often overlooked in the design and interpretation of clinical studies and in the formulation of clinical guidelines.
doi:10.1038/ncpneph0847 | Full Text | PDF (247K)
A primer on recurrent and de novo glomerulonephritis in renal allografts
446Recurrent or de novo glomerulonephritis is a common cause of post-transplantation proteinuria and long-term renal allograft loss. This primer, which is aimed at trainee pathologists and nephrologists who wish to enhance their understanding of the histological basis of the diseases they manage, provides an overview of the prevalence, risk factors, pathogenesis, clinicopathologic features, and clinical implications of recurrent and de novo glomerulonephritis in renal allografts. Treatment options are also briefly summarized.
doi:10.1038/ncpneph0854 | Full Text | PDF (742K)
Case Study
A patient with a juxtaglomerular cell tumor with histological vascular invasion
458Juxtaglomerular cell tumors usually occur during adolescence and early adulthood and are generally deemed benign. Beaudoin et al. report the case of a 51-year-old woman with a juxtaglomerular cell tumor of large size (9.8 cm versus the usual 2–3 cm), which showed histological signs of vascular invasion. Although no other evidence of malignancy was found, this case suggests that adult patients with large juxtaglomerular cell tumors should undergo follow-up after nephrectomy to enable detection of tumor recurrence and metastasis.
doi:10.1038/ncpneph0890 | Full Text | PDF (454K)
Article Response
22q11.2 microdeletion syndrome is a common cause of renal tract malformations
E1doi:10.1038/ncpneph0906 | Full Text
