The third World Kidney Day: looking back and thinking forward

Sudhir V Shah and John Feehally on behalf of the World Kidney Day Steering Committee

doi:10.1038/ncpneph0702 | Full Text | PDF (141K)

Screening for chronic kidney disease in patients with diabetes: are we missing the point?

Merlin C Thomas, GianCarlo Viberti and Per-Henrik Groop

Screening for chronic kidney disease in patients with diabetes should encompass not only testing for albuminuria, but also the subsequent diagnostic procedures and interventions. Otherwise, what is the purpose of testing? The authors of this Viewpoint highlight the inadequacies of current screening practices, and argue that detection of increased urinary albumin excretion in a patient with diabetes should be a call to action.

doi:10.1038/ncpneph0679 | Full Text | PDF (166K)

Coenzyme Q₁₀ deficiency with renal involvement: a newly characterized disorder

doi:10.1038/ncpneph0648 | Full Text | PDF (101K)

A low-cost salt substitute reduces blood pressure in high-risk individuals

doi:10.1038/ncpneph0653 | Full Text | PDF (89K)

Restoring nightly blood pressure dip by altering timing of antihypertensive therapy in CKD

doi:10.1038/ncpneph0667 | Full Text | PDF (89K)

New treatment algorithms for idiopathic glomerular disease

doi:10.1038/ncpneph0657 | Full Text | PDF (91K)

Tacrolimus effective in steroid-dependent minimal change nephrotic syndrome

doi:10.1038/ncpneph0666 | Full Text | PDF (101K)

Bioplorer^® enables rapid quantification of microbial contamination of dialysate

doi:10.1038/ncpneph0632 | Full Text | PDF (98K)

Biocompatible peritoneal dialysis solutions are not superior to conventional solutions

doi:10.1038/ncpneph0659 | Full Text | PDF (87K)

Why do dialysis patients with AMI have such poor outcomes?

doi:10.1038/ncpcardio1052 | Full Text | PDF (88K)

Aspirin prescription does not reduce the risk of cardiac events in patients on hemodialysis

doi:10.1038/ncpneph0646 | Full Text | PDF (88K)

Hemodialysis patients with low vitamin D levels are at increased risk of early mortality

doi:10.1038/ncpneph0656 | Full Text | PDF (99K)

Higher serum creatinine paradoxically associated with better survival in AKI

doi:10.1038/ncpneph0658 | Full Text | PDF (89K)

Pre-emptive management of polyomavirus BK in pediatric kidney transplant recipients

doi:10.1038/ncpneph0664 | Full Text | PDF (99K)

Systematic review of ARB and ACE inhibitor use in kidney transplant recipients

doi:10.1038/ncpneph0631 | Full Text | PDF (90K)

Individualized dosing of MMF is superior to fixed dosing in renal transplant patients

doi:10.1038/ncpneph0665 | Full Text | PDF (90K)

Are oral antibiotics alone efficacious for the treatment of a first episode of acute pyelonephritis in children?

Robert H Mak and Joanne H Wong

doi:10.1038/ncpneph0662 | Full Text | PDF (176K)

Comparing the cerebroprotective properties of antihypertensive drugs in terms of their effects on angiotensin

Thomas Unger

doi:10.1038/ncpneph0672 | Full Text | PDF (175K)

Intravenous methylprednisolone or plasma exchange for adjunctive therapy of severe renal vasculitis?

David J Salant

doi:10.1038/ncpneph0650 | Full Text | PDF (175K)

Previous abdominal surgery is not necessarily a contraindication for peritoneal dialysis

John H Crabtree

doi:10.1038/ncpneph0669 | Full Text | PDF (173K)

Utility of oral valganciclovir for the treatment of cytomegalovirus disease after renal transplantation

David A Pegues

doi:10.1038/ncpneph0642 | Full Text | PDF (175K)

New-onset diabetes after renal transplantation: comparing ciclosporin and tacrolimus

Richard Moore

doi:10.1038/ncpneph0640 | Full Text | PDF (177K)

ACE inhibition after renal transplantation: the effect on persistent left ventricular hypertrophy

Karl H Rahn

doi:10.1038/ncpneph0663 | Full Text | PDF (176K)

Inherited diseases of the glomerular basement membrane

Marie Claire Gubler

Here, Dr Gubler describes the pathogenesis of disorders that affect components of the glomerular basement membrane, including type III and type IV collagen, laminin and fibronectin. Dr Gubler harnesses her considerable clinical experience to recommend diagnostic and management strategies for Alport syndrome, Pierson syndrome, nail–patella syndrome, benign familial hematuria/thin basement membrane nephropathy, and glomerulopathies caused by errant deposition of fibronectin and type III collagen.

doi:10.1038/ncpneph0671 | Full Text | PDF (1,386K)

Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance

Bernhard K Krämer, Tobias Bergler, Benjamin Stoelcker and Siegfried Waldegger

Knowledge regarding this important system of renal chloride transporters has rapidly accumulated. A severe salt-losing tubulopathy—Bartter syndrome type III—develops when ClCKB is non-functional, whereas a common genetic variant of the CLCNKB gene results in salt-dependent hypertension. Disruption of the Barttin gene manifests as Bartter syndrome type IV with sensorineural deafness and an especially severe salt-losing phenotype. It is timely, therefore, to review the properties of these transporters.

doi:10.1038/ncpneph0689 | Full Text | PDF (423K)

Mechanisms of Disease: erythropoietin resistance in patients with both heart and kidney failure

Karien van der Putten, Branko Braam, Kim E Jie and Carlo AJM Gaillard

Anemia is associated with exacerbation of both renal and cardiac disease. A considerable proportion of patients whose anemia is treated with erythropoietin do not respond, and the safety and efficacy of this therapy in people that have both chronic heart and kidney disease has not been proven. Overcoming erythropoietin resistance in this population must be predicated on understanding the processes that contribute to this state. These are reviewed here.

doi:10.1038/ncpneph0655 | Full Text | PDF (458K)