Table of contents
September 2007 Volume 3 No 9
Editorial
Viewpoint
The arduous road to achieving an immunosuppression-free state in kidney transplant recipients
464Since the first successful transplantations were performed around 50 years ago, the lack of improvement in long-term graft survival and the risks associated with immunosuppressive therapy have made the ability to induce tolerance a burning desire among transplantation immunobiologists. These authors outline the considerable challenges that stand in the way of this goal, and proffer their opinion on which strategies are most likely to succeed.
doi:10.1038/ncpneph0568 | Full Text | PDF (135K)
Research Highlights
Nondiabetic renal disease is common in patients with type 2 diabetes
466Whole-gene sequencing for diagnosis of type 1 primary hyperoxaluria
466Eprodisate slows renal function decline in AA amyloidosis
466ACE inhibitors do not delay progression of hypodysplastic nephropathy in children
467Polyflux® 6H dialyzer: a new option for small children requiring dialysis
467Upper arm grafts versus upper arm fistulas following failure of initial forearm fistulas
468Japanese study links hypercalcemia to poor mental health in hemodialysis patients
468Use of kidneys from donors at high risk for HIV or HCV infection should be considered
469Weight loss is associated with reduced urinary albumin excretion
469Typing renal amyloidosis: immunofluorescence staining can be inconclusive
469Heparin-induced thrombocytopenia in the UK hemodialysis population
470Underuse of ACE inhibitors and ARBs in patients with heart failure and renal dysfunction
470Alemtuzumab induction in kidney transplant recipients
471Practice Points
Utility of genetic screening in children with nephrotic syndrome presenting during the first year of life
472doi:10.1038/ncpneph0560 | Full Text | PDF (141K)
Hyperfiltration: a sign of poor things to come in individuals with metabolic syndrome
474doi:10.1038/ncpneph0565 | Full Text | PDF (142K)
Increasing telmisartan vs amlodipine dose in patients with hypertension, type 2 diabetes and microalbuminuria
476doi:10.1038/ncpneph0562 | Full Text | PDF (138K)
N-acetylcysteine for preventing ototoxicity in hemodialysis patients receiving gentamicin
478doi:10.1038/ncpneph0572 | Full Text | PDF (137K)
Dialysis versus conservative management of elderly patients with advanced chronic kidney disease
480doi:10.1038/ncpneph0569 | Full Text | PDF (139K)
The effect of home-care availability on the use of peritoneal dialysis in elderly patients
482doi:10.1038/ncpneph0564 | Full Text | PDF (134K)
Do patients who are aged 70 years or over benefit from deceased donor renal transplantation?
484doi:10.1038/ncpneph0571 | Full Text | PDF (140K)
Reviews
The incidence and implications of aldosterone breakthrough
486Bomback and Klemmer have systematically reviewed the literature on aldosterone breakthrough in people treated with angiotensin-converting-enzyme inhibitors and angiotensin-receptor blockers. Although the data are not yet supportive of widespread screening of asymptomatic patients, the authors contend that physicians should test for this phenomenon in selected patients and consider initiating treatment with aldosterone antagonists or renin inhibitors.
doi:10.1038/ncpneph0575 | Full Text | PDF (285K)
Racial and survival paradoxes in chronic kidney disease
493Although cardiovascular disease is the most common cause of death among people with chronic renal dysfunction, conventional cardiovascular risk factors are paradoxically associated with improved survival in hemodialysis populations. Here, the authors analyze emerging data that support this 'reverse epidemiology'. Confirmation of this phenomenon might lead to the formulation of more effective management strategies, tailored to patient characteristics and disease stage.
doi:10.1038/ncpneph0570 | Full Text | PDF (496K)
Renal function outcomes following liver transplantation and combined liver–kidney transplantation
507Studies of kidney function after orthotopic liver transplantation have yielded conflicting results, and there is a paucity of data on renal outcomes after combined liver–kidney transplantation. In this Review, authors from the University of California, Los Angeles attempt to synthesize the available findings into a cohesive update. Focus is given to the effect of the introduction of the MELD scoring system.
doi:10.1038/ncpneph0574 | Full Text | PDF (341K)
Case Study
Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam
515doi:10.1038/ncpneph0573 | Full Text | PDF (249K)
