Table of contents
August 2007 Volume 3 No 8
Editorial
Acute kidney injury/acute renal failure: standardizing nomenclature, definitions and staging
405doi:10.1038/ncpneph0563 | Full Text | PDF (129K)
Viewpoint
Anemia of chronic kidney disease: CHOIR and the FDA
406Earlier this year, the FDA responded to the findings of CHOIR and several other studies by issuing a Public Health Advisory about the risks associated with erythropoiesis-stimulating agents, and introducing a black box warning to the labeling of these drugs. In this Viewpoint, Ajay K Singh responds to some of the criticisms that have been leveled at CHOIR and offers some practical advice for implementing the FDA's guidance.
doi:10.1038/ncpneph0539 | Full Text | PDF (167K)
Research Highlights
A new dialysis system for premature babies with low birth weight
408doi:10.1038/ncpneph0519 | Full Text | PDF (104K)
pRIFLE: categorizing AKI in critically ill children
408doi:10.1038/ncpneph0533 | Full Text | PDF (114K)
Graduated fill cycles prevent hydrothorax in children on peritoneal dialysis
409doi:10.1038/ncpneph0513 | Full Text | PDF (104K)
Chronic renal dysfunction after pediatric heart transplantation—risk factors identified
409doi:10.1038/ncpneph0534 | Full Text | PDF (114K)
Tacrolimus monotherapy shows efficacy in membranous nephropathy
410doi:10.1038/ncpneph0514 | Full Text | PDF (114K)
Hematocrit targets at for-profit US dialysis facilities are higher than recommended
410doi:10.1038/ncpneph0515 | Full Text | PDF (104K)
Non-aspirin NSAIDs increase the risk of iron deficiency in hemodialysis patients
410doi:10.1038/ncpneph0522 | Full Text | PDF (104K)
Kidneys can be safely harvested from transfusion-refusing living donors
411doi:10.1038/ncpneph0521 | Full Text | PDF (115K)
Factors that might affect risk of gadodiamide-related nephrogenic systemic fibrosis
411doi:10.1038/ncpneph0523 | Full Text | PDF (105K)
Postoperative heparin not routinely needed in low-risk renal transplant recipients
412doi:10.1038/ncpneph0516 | Full Text | PDF (115K)
A small proportion of living kidney donors experience donation-related insurance problems
412doi:10.1038/ncpneph0520 | Full Text | PDF (103K)
Good outcomes with ABO-incompatible transplantation: report from three centers
413doi:10.1038/ncpneph0531 | Full Text | PDF (105K)
Good long-term outcome with non-heartbeating kidney transplantation
413doi:10.1038/ncpneph0532 | Full Text | PDF (105K)
Practice Points
Which is the best duplex sonographic parameter to use when screening for renal artery stenosis?
414doi:10.1038/ncpneph0537 | Full Text | PDF (162K)
Age as a factor in the decision to refer patients with chronic kidney disease for vascular access creation
416doi:10.1038/ncpneph0543 | Full Text | PDF (165K)
Should clinicians follow the K/DOQI guidelines for treating hyperphosphatemia with sevelamer?
418doi:10.1038/ncpneph0536 | Full Text | PDF (140K)
Could diuretics be beneficial in patients on hemodialysis?
420doi:10.1038/ncpneph0542 | Full Text | PDF (136K)
Far-infrared irradiation can improve blood flow and patency of arteriovenous fistulas in hemodialysis patients
422doi:10.1038/ncpneph0538 | Full Text | PDF (137K)
Worse renal transplant outcomes with sirolimus–mycophenolate than with calcineurin inhibitor regimens
424doi:10.1038/ncpneph0530 | Full Text | PDF (137K)
Minimizing ciclosporin in renal transplant recipients on daclizumab, mycophenolate and steroids
426doi:10.1038/ncpneph0540 | Full Text | PDF (139K)
Reviews
Appropriate blood pressure control in hypertensive and normotensive type 2 diabetes mellitus: a summary of the ABCD trial
428The Appropriate Blood Pressure Control in Diabetes (ABCD) study remains one of the most relevant sources of data on the vexed issue of optimum management of blood pressure in diabetic patients. This Review by trial investigators provides a more-comprehensive description of data that have emerged from this 5-year, randomized study of moderate versus intensive control of blood pressure using either a calcium channel blocker or an ACE inhibitor.
doi:10.1038/ncpneph0559 | Full Text | PDF (479K)
Improving outcomes of acute kidney injury: report of an initiative
439The Acute Kidney Injury Network (AKIN) met in Amsterdam, The Netherlands, in September 2005. At the 2-day meeting, participants in this multidisciplinary collaboration proposed a standard definition, and scheme for the classification, of AKI. Widespread adoption of these standards, presented here by members of the AKIN working group, would help to advance the study of this condition, and improve patient outcomes.
doi:10.1038/ncpneph0551 | Full Text | PDF (175K)
Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues
443The authors provide a brief overview of the physiological and pharmacological relevance of proteins that translocate organic anions. Focusing on OATs located in the basolateral membrane of proximal tubule cells, the authors discuss data from Xenopus oocytes and knockout mice. The potential for new findings to shed light on an individual patient's response to treatment with a particular drug, and the risks of toxic effects, are emphasized.
doi:10.1038/ncpneph0558 | Full Text | PDF (236K)
Mechanisms of Disease: what can mouse models tell us about the molecular processes underlying Dent disease?
449Elucidating the mechanisms that contribute to disease development often requires experiments that are difficult to perform in patients. Mutant mice that recapitulate the characteristics of the X-linked disorder Dent disease have proved to be useful experimental surrogates. Here, an investigator involved in development of one of these mouse models summarizes the most clinically relevant data that have been generated to date.
doi:10.1038/ncpneph0541 | Full Text | PDF (312K)
Case Study
Four cases of nafcillin-associated acute interstitial nephritis in one institution
456doi:10.1038/ncpneph0561 | Full Text | PDF (309K)
Article Response
The role of the nephrologist in the treatment of lupus nephritis
E1doi:10.1038/ncpneph0552 | Full Text
