Table of contents
June 2007 Volume 3 No 6
Viewpoint
Why are rheumatologists treating lupus nephritis?
296A group chaired by a rheumatologist recently published a consensus document in Arthritis and Rheumatism that codified definitions of renal responses and non-responses to therapy in patients with lupus nephritis. In this Viewpoint, the co-director of a renal-rheumatology lupus clinic argues that nephrologists have a key role to play in the diagnosis and treatment of lupus nephritis, and that they should not allow rheumatologists to take over the management of this condition.
Research Highlights
High target hemoglobin levels increase risk of death in CKD patients receiving erythropoietin
298Cigarette smoking is associated with albuminuria in hypertensive adults in the US
298Model identifies individuals at high risk of occult chronic kidney disease
298Falls in systolic blood pressure during hemodialysis relate to good short-term outcome
299Ionic dialysance shows promise for quantification of dialysis dose in acute renal failure
299Weight loss in renal transplant candidates does not improve post-transplantation outcome
300Phosphate binder choice affects risk of death in hemodialysis patients
300Risk of renal failure after bariatric surgery in patients with kidney stones
301Use of a timesheet cuts cold ischemia time of donor kidneys by 8 hours
301Abdominal aortic calcification predicts mortality in hemodialysis patients
301Reprocessing of formalin-fixed tissue for EM precludes accurate TBMN diagnosis
302Mycophenolate mofetil treatment for resistant primary glomerulonephritis
302Cinacalcet not cost-effective in secondary hyperparathyroidism
303Practice Points
Intensive versus moderate blood-pressure control in normotensive patients with type 2 diabetes
304Risk of contrast-induced nephropathy in patients with normal renal function: iso-osmolar versus low-osmolar medium
306Taking the weight off the fistula: the importance of vein transposition and fistula evaluation in obese patients
308What is the best way of screening hemodialysis patients for latent tuberculosis?
310Should kidney transplantation be delayed in adolescents?
312Screening for fracture risk is mandatory in renal transplant patients on even low-dose maintenance steroids
314Reviews
Management of growth retardation in pediatric recipients of renal allografts
318Unfortunately, dialysis and kidney transplantation do not always ameliorate the retarded growth that is a feature of pediatric end-stage renal disease. This discussion encompasses the main factors that affect the growth of children after transplantation, including age at transplantation, function of the grafted kidney and use of corticosteroids. Evidence for and against the use of recombinant human growth hormone in this patient population is presented.
doi:10.1038/ncpneph0502 | Full Text | PDF (250K)
The genetics of IgA nephropathy
325The authors present the latest evidence supporting genetic contributions to IgA nephropathy, a common form of primary glomerulonephritis throughout the world. No specific causative gene has yet been detected, but defective glycosylation of IgA1 leading to formation of immune complexes has been consistently implicated. The prevalence of familial forms of the condition varies depending on geography and ethnicity. The clinical patterns of these under-recognized familial forms are reviewed here.
doi:10.1038/ncpneph0492 | Full Text | PDF (393K)
Hypothesis—haptoglobin genotype and diabetic nephropathy
339A group from Technion, Israel, presents data to support an association between diabetic complications and the pattern of inheritance of alleles for the hemoglobin-binding protein haptoglobin. Experimental and preliminary clinical evidence indicate that the antioxidant protection conferred by haptoglobin is dependent upon genotype. Confirmation of the hypothesis will provide the rationale for trials of genotype-guided antioxidant therapies in diabetic populations.
doi:10.1038/ncpneph0467 | Full Text | PDF (173K)
Case Study
Pseudotumor of gout in the patella of a kidney transplant recipient
345doi:10.1038/ncpneph0494 | Full Text | PDF (558K)
Article Responses
Tranexamic acid and uremic bleeding: evidence-based treatment recommendations
E2doi:10.1038/ncpneph0528 | Full Text
Authors' response to "Tranexamic acid and uremic bleeding: evidence-based treatment recommendations"
E3doi:10.1038/ncpneph0529 | Full Text
