Of microbes and machines

Suzanne J Farley

doi:10.1038/ncpneph0612 | Full Text | PDF (94K)

Vascular calcification in chronic kidney disease: the role of vitamin K

Rachel M Holden and Sarah L Booth

This Viewpoint puts forward the intriguing hypothesis that vitamin K is a modifiable risk factor for vascular calcification in patients on dialysis. Reports linking vitamin K with regulation of vascular calcification via the actions of matrix GLA protein are set in the context of the authors' own data on the incidence of subclinical vitamin K deficiency and the use of the vitamin K antagonist warfarin in the dialysis setting.

doi:10.1038/ncpneph0601 | Full Text | PDF (133K)

The Framingham equation does not accurately predict cardiac events in the CKD population

doi:10.1038/ncpneph0591 | Full Text | PDF (111K)

Cystatin C levels are highly predictive of outcome in chronic kidney disease

doi:10.1038/ncpneph0592 | Full Text | PDF (99K)

Oral antibiotics alone can be used to treat pediatric acute pyelonephritis

doi:10.1038/ncpneph0595 | Full Text | PDF (129K)

The treatment of severe lupus nephritis with mycophenolate mofetil—a meta-analysis

doi:10.1038/ncpneph0578 | Full Text | PDF (129K)

Enzyme replacement therapy in patients with Fabry disease and end-stage renal disease

doi:10.1038/ncpneph0579 | Full Text | PDF (111K)

Machine-generated bicarbonate dialysate customized for patients with acute renal failure

doi:10.1038/ncpneph0593 | Full Text | PDF (129K)

Intraperitoneal electrolytes in peritoneal dialysis: an alternative to oral supplements?

doi:10.1038/ncpneph0594 | Full Text | PDF (110K)

Comparing vaccine responses in CNI-treated and sirolimus-treated transplant recipients

doi:10.1038/ncpneph0581 | Full Text | PDF (128K)

Preserving donated kidneys using machine perfusion improves 5-year allograft survival

doi:10.1038/ncpneph0582 | Full Text | PDF (101K)

Can renal tubular hypokalemic disorders be accurately diagnosed on the basis of the diuretic response to thiazide?

Martin C Sassen, Nikola Jeck and Günter Klaus

doi:10.1038/ncpneph0576 | Full Text | PDF (137K)

Dual blockade of the renin–angiotensin–aldosterone system in patients with diabetic nephropathy

Yolanda E Bogaert

doi:10.1038/ncpneph0599 | Full Text | PDF (139K)

Cyclophosphamide plus steroids for membranous nephropathy with nephrotic syndrome: long-term outcomes

Jack F M Wetzels

doi:10.1038/ncpneph0586 | Full Text | PDF (139K)

Is there a simpler and more equitable way of using HLA data to allocate deceased donor kidneys?

M Sue Leffell and Andrea A Zachary

doi:10.1038/ncpneph0584 | Full Text | PDF (138K)

How high is the risk of ANCA-associated vasculitis recurring after renal transplantation?

Alan D Salama

doi:10.1038/ncpneph0585 | Full Text | PDF (136K)

Parvovirus-B19-associated complications in renal transplant recipients

Meryl Waldman and Jeffrey B Kopp

There is currently insufficient evidence to recommend screening of kidney allograft donors and recipients for parvovirus B19 infection. As such, physicians managing recipients need to have a high index of suspicion, and include this type of infection in their differential diagnosis of chronic anemia and other cytopenias in the post-transplantation period. Here, Waldman and Kopp from the NIH review the pathogenesis, diagnosis and management of parvovirus B19 infection.

doi:10.1038/ncpneph0609 | Full Text | PDF (362K)

Technology Insight: innovative options for end-stage renal disease—from kidney refurbishment to artificial kidney

Branko Braam, Marianne C Verhaar, Peter Blankestijn, Walther H Boer and Jaap A Joles

This wide-ranging introduction to new technologies for the management of renal failure touches on the optimization of conventional dialysis and on alternative techniques such as transplantation methods, artificial kidneys, tissue engineering strategies and harnessing the regenerative capacity of stem cells. The potential for other organs to 'host' renal functions, and the co-opting of developmental plasticity, are also discussed.

doi:10.1038/ncpneph0600 | Full Text | PDF (302K)