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Renal injury

Early apoptotic extracellular vesicles in injury and repair

During injury, mitogenic signals from apoptotic cells may compensate for cell loss by promoting organ homeostasis and regeneration. A distinct type of early apoptotic extracellular vesicle with specific mitogenic activity has been identified. The detection of these vesicles in damaged mouse glomeruli highlights their possible role in response to renal injury.

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Figure 1: Intranephron vesicular communication.

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Acknowledgements

The authors acknowledge support from the National Center for Advancing Translational Sciences of the US National Institutes of Health (UH2TR000880, UH3TR000880-03S1). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Correspondence to Giovanni Camussi.

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The authors declare that they have received grant support from Unicyte AG, Switzerland.

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Bussolati, B., Camussi, G. Early apoptotic extracellular vesicles in injury and repair. Nat Rev Nephrol 13, 523–524 (2017). https://doi.org/10.1038/nrneph.2017.117

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