A new study reports that a heart–brain–kidney network involving renal and cardiac macrophages is required for the adaptive response to cardiac stress. As well as highlighting the importance of inter-organ communication in complex pathological syndromes, the findings raise important questions with implications for the treatment of heart failure.
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Silljé, H., de Boer, R. Macrophages take centre stage in the heart–brain–kidney axis. Nat Rev Nephrol 13, 388–390 (2017). https://doi.org/10.1038/nrneph.2017.73
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DOI: https://doi.org/10.1038/nrneph.2017.73
