T cells mediate injury in glomerulonephritis but mice devoid of T cells and B cells can also develop this disease. A new study shows that expression of the cytokine receptor common subunit γ and IL-15 in podocytes protects against crescentic glomerulonephritis, independent of B cells, T cells and natural killer cells.
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Webster, P., Pusey, C. Crescentic glomerulonephritis: beyond the immune system. Nat Rev Nephrol 13, 198–200 (2017). https://doi.org/10.1038/nrneph.2017.32
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DOI: https://doi.org/10.1038/nrneph.2017.32