Blood pressure (BP) goals and the management of BP in patients with chronic kidney disease (CKD) remain controversial topics. Key articles in the past year have addressed BP goals in CKD, the use of new agents to slow CKD progression and the effects of visit-to-visit variability in systolic BP on cardiovascular events and renal progression in patients with CKD.
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References
Peralta, C. A. et al. Blood pressure components and end-stage renal disease in persons with chronic kidney disease: the Kidney Early Evaluation Program (KEEP). Arch. Intern. Med. 172, 41–47 (2012).
James, P. A. et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311, 507–520 (2014).
Ambrosius, W. T. et al. The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). Clin. Trials 11, 532–546 (2014).
Wright, J. T. Jr. A randomized trial of intensive versus standard blood-pressure control. N. Engl. J. Med. 373, 2103–2116 (2015).
Xie, X. et al. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet 387, 435–443 (2016).
Cooper-DeHoff, R. M. & Johnson, J. A. Hypertension pharmacogenomics: in search of personalized treatment approaches. Nat. Rev. Nephrol. 12, 110–122 (2016).
Wanner, C. et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N. Engl. J. Med. 375, 323–334 (2016).
Diaz, K. M. et al. Visit-to-visit variability of blood pressure and cardiovascular disease and all-cause mortality: a systematic review and meta-analysis. Hypertension 64, 965–982 (2014).
Chang, T. I. et al. Visit-to-visit systolic blood pressure variability and outcomes in hemodialysis. J. Hum. Hypertens. 28, 18–24 (2014).
Chang, T. I., Tabada, G. H., Yang, J., Tan, T. C. & Go, A. S. Visit-to-visit variability of blood pressure and death, end-stage renal disease, and cardiovascular events in patients with chronic kidney disease. J. Hypertens. 34, 244–252 (2016).
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D.L.C. and R.R.T. are SPRINT study investigators.
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Cohen, D., Townsend, R. Blood pressure goals, variability and SGLT2 blockade in CKD. Nat Rev Nephrol 13, 75–76 (2017). https://doi.org/10.1038/nrneph.2016.189
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DOI: https://doi.org/10.1038/nrneph.2016.189
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