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Hypertension in 2016

Blood pressure goals, variability and SGLT2 blockade in CKD

Blood pressure (BP) goals and the management of BP in patients with chronic kidney disease (CKD) remain controversial topics. Key articles in the past year have addressed BP goals in CKD, the use of new agents to slow CKD progression and the effects of visit-to-visit variability in systolic BP on cardiovascular events and renal progression in patients with CKD.

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References

  1. Peralta, C. A. et al. Blood pressure components and end-stage renal disease in persons with chronic kidney disease: the Kidney Early Evaluation Program (KEEP). Arch. Intern. Med. 172, 41–47 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  2. James, P. A. et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311, 507–520 (2014).

    Article  CAS  PubMed  Google Scholar 

  3. Ambrosius, W. T. et al. The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). Clin. Trials 11, 532–546 (2014).

    Article  PubMed  Google Scholar 

  4. Wright, J. T. Jr. A randomized trial of intensive versus standard blood-pressure control. N. Engl. J. Med. 373, 2103–2116 (2015).

    Article  CAS  PubMed  Google Scholar 

  5. Xie, X. et al. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet 387, 435–443 (2016).

    Article  PubMed  Google Scholar 

  6. Cooper-DeHoff, R. M. & Johnson, J. A. Hypertension pharmacogenomics: in search of personalized treatment approaches. Nat. Rev. Nephrol. 12, 110–122 (2016).

    Article  CAS  PubMed  Google Scholar 

  7. Wanner, C. et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N. Engl. J. Med. 375, 323–334 (2016).

    Article  CAS  PubMed  Google Scholar 

  8. Diaz, K. M. et al. Visit-to-visit variability of blood pressure and cardiovascular disease and all-cause mortality: a systematic review and meta-analysis. Hypertension 64, 965–982 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chang, T. I. et al. Visit-to-visit systolic blood pressure variability and outcomes in hemodialysis. J. Hum. Hypertens. 28, 18–24 (2014).

    Article  CAS  PubMed  Google Scholar 

  10. Chang, T. I., Tabada, G. H., Yang, J., Tan, T. C. & Go, A. S. Visit-to-visit variability of blood pressure and death, end-stage renal disease, and cardiovascular events in patients with chronic kidney disease. J. Hypertens. 34, 244–252 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Debbie L. Cohen or Raymond R. Townsend.

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D.L.C. and R.R.T. are SPRINT study investigators.

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Cohen, D., Townsend, R. Blood pressure goals, variability and SGLT2 blockade in CKD. Nat Rev Nephrol 13, 75–76 (2017). https://doi.org/10.1038/nrneph.2016.189

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