A recent meta-analysis reports that blood-pressure-lowering treatments reduce the rate of cardiovascular events in patients with baseline systolic blood pressures ranging from >160 mmHg to <130 mmHg. Notwithstanding their diverse data sources, the researchers assert that a blood pressure target of <130 mmHg should be adopted when treating hypertension.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Pre-pregnancy blood pressure and pregnancy outcomes: a nationwide population-based study
BMC Pregnancy and Childbirth Open Access 19 March 2022
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lewington, S., Clarke, R., Oizibash, N., Peto, R. & Collins, R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual date for one million adults in 61 prospective studies. Lancet 360, 1903–1191 (2002).
Lackland, D. T. et al. Factors influencing the decline in stroke mortality: a statement from the American Heart Association/American Stroke Association. Stroke 45, 315–353 (2014).
Ettehad, D. et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet http://dx.doi.org/10.1016/S0140-6736(15)01225-8 (2015).
Wright, J. T. et al. A randomized trial of intensive versus standard blood pressure control. N. Engl. J. Med. 373, 2103–2116 (2015).
Cushman, W. C. et al. Effects of intensive blood pressure control in type 2 diabetes mellitus. N. Engl. J. Med. 362, 1575–1585 (2010).
Weber, M. A. et al. Cardiovascular outcomes according to systolic blood pressure in patients with and without diabetes: an ACCOMPLISH substudy. J. Clin. Hypertens. (in press).
PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood pressure lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 358, 1033–1041 (2001).
Yusuf, S. et al. Effects of an angiotensin converting enzyme inhibitor, ramipril, on cardiovascular events in high risk patients. N. Engl. J. Med. 342, 145–153 (2000).
Weber, M. A. et al. Cardiovascular events during differing hypertension therapies in patients with diabetes. J. Am. Coll. Cardiol. 56, 77–85 (2010).
Weber, M. A. et al. Cardiovascular outcomes in hypertensive patients: comparing single-agent therapy with combination therapy. J. Hypertens. 30, 2213–2222 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Weber, M., Lackland, D. Cardiovascular benefits of lowering blood pressure. Nat Rev Nephrol 12, 202–204 (2016). https://doi.org/10.1038/nrneph.2016.27
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2016.27
This article is cited by
-
Pre-pregnancy blood pressure and pregnancy outcomes: a nationwide population-based study
BMC Pregnancy and Childbirth (2022)
-
Hypertension Across the Atlantic: A Sprint or a Marathon?
High Blood Pressure & Cardiovascular Prevention (2017)