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Transplantation

Biomarkers in transplantation—the devil is in the detail

Nature Reviews Nephrology volume 11, pages 204–205 (2015)Cite this article

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Numerous studies have suggested the utility of non-invasive molecular biomarkers to monitor recipients of kidney transplants. A new correlation-based algorithm using stepwise analysis of gene expression data from peripheral blood samples, claiming to detect subclinical, and predict clinical acute allograft rejection, requires corroboration before testing in prospective validation studies.

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Authors and Affiliations

  1. Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair, Suite 1900, Chicago, 60611, IL, USA

    Michael Abecassis

  2. Department of Nephrology and Hypertension, University of Kansas Medical Centre, 3901 Rainbow Boulevard, Kansas City, 66160, KS, USA

    Bruce Kaplan

Authors
  1. Michael Abecassis
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  2. Bruce Kaplan
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Corresponding author

Correspondence to Michael Abecassis.

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Competing interests

M.A. is co-founder and Chief Clinical Advisor of Transplant Genomics Incorporated. B.K. declares no competing interests.

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Abecassis, M., Kaplan, B. Biomarkers in transplantation—the devil is in the detail. Nat Rev Nephrol 11, 204–205 (2015). https://doi.org/10.1038/nrneph.2015.2

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