Klotho deficiency is a mediator of pathologic cardiac remodelling, and fibroblast growth factor (FGF)-23 might contribute to this process in the settings of chronic kidney disease (CKD) and ageing, conclude the authors of a new study. Hu et al. found that mice with Klotho deficiency—achieved by genetic modification, a high-phosphate diet, ageing or CKD—exhibited cardiac remodelling. FGF-23 level correlated with cardiac remodelling in Klotho-deficient but not Klotho-replete mice.
References
Hu, M. C. et al. Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J. Am. Soc. Nephrol. 10.1681/ASN.2014050465
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Role for Klotho and phosphate in cardiac remodelling. Nat Rev Nephrol 10, 674 (2014). https://doi.org/10.1038/nrneph.2014.208
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DOI: https://doi.org/10.1038/nrneph.2014.208
