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Transplantation

Recognizing self versus non-self: new territory for monocytes

Nature Reviews Nephrology volume 10, pages 548–549 (2014)Cite this article

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The role of the innate immune system in mediating allograft rejection is unclear. A new study demonstrates for the first time the ability of allografts to stimulate the differentiation of monocytes into inflammatory dendritic cells, which produce IL-12 and stimulate T cells, leading to graft rejection.

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Figure 1: Potential role of monocytes in allograft rejection.

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Authors and Affiliations

  1. Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, 63110, MO, USA

    Deepak K. Nayak

  2. Departments of Surgery, Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, 63110, MO, USA

    Thalachallour Mohanakumar

Authors
  1. Deepak K. Nayak
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  2. Thalachallour Mohanakumar
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Correspondence to Thalachallour Mohanakumar.

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The authors declare no competing financial interests.

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Nayak, D., Mohanakumar, T. Recognizing self versus non-self: new territory for monocytes. Nat Rev Nephrol 10, 548–549 (2014). https://doi.org/10.1038/nrneph.2014.144

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