Table of contents
December 2005 Volume 1 No 2
Editorial
Viewpoint
Recurrence of lupus nephritis after renal transplantation: if we look for it, will we find it?
62Recurrence of lupus nephritis after kidney transplantation is often regarded as rare, and transplantation of patients with end-stage renal disease secondary to this condition is common. Several studies, however, have reported a higher incidence of recurrence of lupusnephritis after renal transplantation than the 1–4% which is usually quoted. Weng and Goral discuss reasons for the variation in reported incidence of recurrent lupus nephritis and consider the potential clinical impact of recurrence.
Research Highlights
Locking catheters with trisodium citrate reduces infection during hemodialysis
64Birth weight, gestational age and the risk of renal disease
64Parathyroidectomy might reduce cardiovascular calcification in dialysis patients
64RAS gene mutations linked to autosomal recessive renal tubular dysgenesis
65Equation improves dialysis management of methanol and ethylene glycol poisoning
65BOLD MRI in the detection of early renal transplant rejection
66A link between pediatric mitochondrial diseases and renal disorders
66Enzymes plus detergent effective in cleaning hemodialysis machines
67Practice Points
Can serial measurements of cystatin C accurately detect early renal function decline?
68Does full versus partial correction of anemia have additional cardiac benefit in incident hemodialysis patients?
70Can urine polypeptide profiles be used to diagnose IgA nephropathy?
72How does alemtuzumab affect long-term graft and patient outcomes after deceased-donor kidney transplantation?
74Is tacrolimus associated with fewer surgical complications than ciclosporin after kidney–pancreas transplantation?
76Reviews
Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
80The escalating burden of diabetic nephropathy is largely a function of the increased frequency of type 2 diabetes, which is associated with obesity and the metabolic syndrome. Prevention is dependent on elucidation of causal mechanisms. Here, Richard Johnson and colleagues present evidence for a mechanism that might form the basis of novel intervention strategies.
doi:10.1038/ncpneph0019 | Full Text | PDF (177K)
Mechanisms of Disease: cell death in acute renal failure and emerging evidence for a protective role of erythropoietin
87Does erythropoietin have the potential to ameliorate renal injury in humans? This article addresses this question in the context of our current understanding of the pathophysiology of acute renal failure. Recent findings from experimental models are presented, and their relevance to mechanisms of acute renal failure—including endothelial and tubular cell injury, and inflammation—are discussed.
doi:10.1038/ncpneph0042 | Full Text | PDF (217K)
Mechanisms of Disease: pre-eclampsia
98In this comprehensive review, Giuseppe Remuzzi and colleagues present a hypothesis for the pathophysiology of pre-eclampsia that unifies findings from a recent flurry of research. These new insights should spur the development of novel treatments for the hypertension and proteinuria that are hallmarks of this leading cause of fetal and maternal morbidity.
doi:10.1038/ncpneph0035 | Full Text | PDF (334K)
Case Study
Cystic kidney disease, chromophobe renal cell carcinoma and TCF2 (HNF1
) mutations
115doi:10.1038/ncpneph0054 | Full Text | PDF (335K)
