Nature Reviews Nephrology
Volume 12, No 12 December 2016
Featured Article
The impact of insulin resistance on the kidney and vasculature
Ferruh Artunc, Erwin Schleicher, Cora Weigert, Andreas Fritsche, Norbert Stefan & Hans-Ulrich Häring
Here, the authors discuss the mechanisms and effects of insulin resistance in the kidney and vasculature as well as therapeutic approaches to improve insulin sensitivity.
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2015 2-year Impact Factor 9.463 Journal Metrics 2-year Median 8Source of Impact Factor data)
Current Issue
Review
Nanomedicines for renal disease: current status and future applications
Nazila Kamaly, John C. He, Dennis A. Ausiello & Omid C. Farokhzad
The use of nanoparticles has great potential for targeted delivery of therapeutics to specific cell types in the kidney. Here, the authors discuss the characteristics of nanoparticles and of renal physiology that must be considered when developing nanomedicines to treat kidney disease, as well as the remaining challenges in clinical translation of this technology.
Current Issue
Review
The contribution of branching morphogenesis to kidney development and disease
Kieran M. Short & Ian M. Smyth
In this Review, the authors discuss spatial, temporal and molecular features of nephron formation through branching morphogenesis during kidney development. They also reflect on how genetic and environmental factors can alter these mechanisms and decrease nephron endowment in the adult kidney.
Current Issue
Perspectives
Minimal change disease and idiopathic FSGS: manifestations of the same disease
Rutger J. Maas, Jeroen K. Deegens, Bart Smeets, Marcus J. Moeller & Jack F. Wetzels
Minimal change disease and idiopathic focal segmental glomerulosclerosis are often described as separate disease entities. Here, the authors propose that they are in fact different manifestations of the same disease process and review the evidence that led to this hypothesis.
Current Issue
News and Views
Genetics: Genetic factors in the regulation of blood pressure
Nicholette D. Palmer & Barry I. Freedman
Sepsis: Vasopressin: a first-line agent for septic shock?
Jean-Louis Vincent & Emiel H. Post
Noticeboard
Poster: Hyperkalaemia
Hyperkalaemia is an electrolyte abnormality that is associated with cardiac arrhythmias and an increased risk of mortality. It is particularly common in patients with chronic kidney disease, owing to the effects of renal dysfunction on potassium homeostasis, the presence of concomitant comorbidities and the use of drugs that increase the risk of hyperkalaemia. Here, Csaba Kovesdy and Faiez Zannad describe the aetiology of hyperkalaemia; homeostatic mechanisms involved in maintaining potassium balance, including the role of the kidney in this process; the cardiovascular consequences of hyperkalaemia; and therapeutic strategies.
This poster is freely available thanks to support from Relypsa, Inc.
Poster: Hyperphosphataemia in CKD
Renal excretion of dietary phosphate has an important role in the maintenance of phosphate homeostasis. In patients with late-stage chronic kidney disease (CKD), nephron loss and the inability of adaptive mechanisms to maintain phosphate excretion lead to phosphate retention. The resulting hyperphosphataemia is associated with increased cardiovascular risk in these patients. This poster outlines the pathophysiology of hyperphosphataemia in CKD and the potential adverse effects of excess phosphate on the heart, bone and vasculature.
This poster is freely available thanks to support from Keryx Biopharmaceuticals, Inc.
Focus on translational immunology in kidney disease
This focus aims to provide insights into new developments in the identification of appropriate therapeutic targets in immune-mediated kidney disease, and stimulate discussion as to how the translation of therapies to the clinic can be improved.
Collection on paediatric kidney disease
The focus of World Kidney Day 2016 is 'kidney disease and children'. To mark this occasion, Nature Reviews Nephrology presents a special collection of Reviews and opinion pieces on paediatric kidney disease. The articles in this collection discuss topics including new insights into the genetic basis of various paediatric renal diseases, transplantation outcomes in children, and the effects of maternal, fetal, and childhood nutrition on long-term renal outcomes. In a specially commissioned Viewpoint article, six leading researchers reflect on progress in various fields of paediatric nephrology and the challenges that remain to be overcome.
Collection on fibrosis: mechanisms and targets
The collection consists of Reviews and Research articles from several Nature journals, describing the latest advances in fibrosis research in various organs, including the liver, kidney, heart, skin and lung. It also includes relevant News and Opinion articles and additional content, including a selection of peer-reviewed procedures from Nature Protocols, and a PrimeView, which summarizes the main features of systemic sclerosis.
Key advances in medicine ebook
The world of medicine is fast-paced and ever-changing; the Key Advances in Medicine eBook is bursting with information for medical students, physicians and clinical researchers wishing to keep up with the most significant medical breakthroughs of the past year. This eBook, which is free to download for registered users, contains 44 articles summarizing the key clinical and biomedical studies published in 2015 and highlighting the trends to watch out for in 2016. The articles are written by international experts who identify the top ground-breaking research papers within their speciality.
A decade in medicine ebook
In this special collection of 47 articles—commissioned to celebrate the 10th anniversary of the launch of the clinical Nature Reviews journals—leading experts highlight the most important advances in eight medical specialties between 2004 and 2015, and comment on future developments in their fields.
Focus on 10th anniversary
November 2015 marked the 10th anniversary of Nature Reviews Nephrology. To mark this occasion, we present an anniversary issue containing specially commissioned articles that highlight progress in nephrology over the past decade.
Focus on nephrology in the developing world
This focus aims to shed light on a range of issues facing the renal health of the developing world, from infectious agents that manifest in the kidneys to setting up treatment facilities in challenging circumstances.
Conferences
Click here to find out what's on the Nephrology conference circuit and which meetings will be attended by the editors of Nature Reviews Nephrology.
Collection on clinical applications of next-generation sequencing
This Nature Collection highlights the breadth of applications of next-generation sequencing technologies in the clinic and the importance of the insights that are being gained through these methods to improve health.
Collection on podocyte biology
This Collection of articles discusses important aspects of podocyte structure and function and describes how advances in our understanding of these areas are increasing our knowledge of the pathogenesis of glomerular disease.
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Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.
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