Renal transplantation: Making kidneys count

Rebecca Ireland

doi:10.1038/nrneph.2012.86

Nature Reviews Nephrology 8, 311 (2012)

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Increasing the pool of deceased donor organs for kidney transplantation

Jesse D. Schold & Dorry L. Segev

doi:10.1038/nrneph.2012.60

Nature Reviews Nephrology 8, 325-331 (2012)

The number of candidates awaiting kidney transplantation has grown substantially over the past few decades, but the number of available organs has increased only modestly. Barring any notable progress in technology, improving the fate of transplant candidates will rely heavily on increasing the pool of available donor organs. This Review outlines prominent proposed interventions that may increase the deceased kidney donor pool and discusses issues concerning their implementation and effectiveness.

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Innovative strategies in living donor kidney transplantation

Dorry L. Segev

doi:10.1038/nrneph.2012.82

Nature Reviews Nephrology 8, 332-338 (2012)

Live donor kidney transplantation has decreased over the past few years and innovative strategies are needed to increase the donor pool. In this Review, Dorry Segev discusses recent clinical innovations that minimize the barrier to donation, including changes in surgical technique, kidney paired donation, incompatible transplantation as well as educational and outreach programs.

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New strategies to optimize kidney recovery and preservation in transplantation

Delphine Bon, Nicolas Chatauret, Sébastien Giraud, Raphael Thuillier, Frédéric Favreau & Thierry Hauet

doi:10.1038/nrneph.2012.83

Nature Reviews Nephrology 8, 339-347 (2012)

Optimizing kidney preservation is a primary concern in transplantation, particularly in relation to new donor sources, such as expanded criteria donors and donation after cardiac death. Here, the authors describe emerging strategies to prevent ischemia–reperfusion injuries in donor kidneys and describe innovative interventions at the donor, graft preservation or recipient levels to improve recovery, evaluation and outcome of kidney grafts.

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The impact of donor-specific anti-HLA antibodies on late kidney allograft failure

Alexandre Loupy, Gary S. Hill & Stanley C. Jordan

doi:10.1038/nrneph.2012.81

Nature Reviews Nephrology 8, 348-357 (2012)

Although outcomes of renal transplantation have improved in recent times, kidney allograft loss remains substantial. A major advance of the past decade has been the demonstration of the destructive power of anti-HLA alloantibodies and their association with antibody-mediated rejection (ABMR). The authors of this Review present the new entities and concepts that have emerged to expand our knowledge of the spectrum of ABMR and some aspects of the natural history of antibody-mediated kidney allograft deterioration.

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The Declaration of Istanbul—early impact and future potential

Gabriel M. Danovitch & Mustafa Al-Mousawi

doi:10.1038/nrneph.2012.59

Nature Reviews Nephrology 8, 358-361 (2012)

The Declaration of Istanbul on Organ Trafficking and Transplant Tourism was formulated at an international meeting held in 2008 with the aim of promoting the welfare of living organ donors in the context of improved global organ transplantation practice. In this Perspectives article, Danovitch and Al-Mousawi provide an update on this endeavor, specifically discussing promulgation of the Declaration, how it has been put into action and legislative changes that have since come into effect.

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