Carl Conway

Paradigms of acute kidney injury in the intensive care setting

Latest Reviews

  • Review |

    Exposure to environmental pollutants is a major cause of kidney injury and disease worldwide and is a particular problem in the developing world. In this Review, the authors discuss the different environmental pollutants that affect the kidney, and our understanding of the pathogenic mechanisms of environmental pollutants in kidney injury and disease.

    • Xin Xu
    • , Sheng Nie
    • , Hanying Ding
    •  & Fan Fan Hou
  • Review |

    Dysfunctional mitochondria are postulated to be central to the development and progression of diabetic kidney disease (DKD). Here, the authors review the role of mitochondrial dysfunction in the pathogenesis of DKD and novel therapeutic strategies to target mitochondria and improve kidney function.

    • Josephine M. Forbes
    •  & David R. Thorburn
  • Review |

    Monoclonal immunoglobulin deposition produces complex diseases with heterogeneous phenotypes, making it difficult to identify the underlying mechanisms of immunoglobulin aggregation and deposition. In this Review, the authors discuss animal models of various human immunoglobulin deposition diseases, and each model's drawbacks and contributions to our understanding of these diseases.

    • Christophe Sirac
    • , Guillermo A. Herrera
    • , Paul W. Sanders
    • , Vecihi Batuman
    • , Sebastien Bender
    • , Maria V. Ayala
    • , Vincent Javaugue
    • , Jiamin Teng
    • , Elba A. Turbat-Herrera
    • , Michel Cogné
    • , Guy Touchard
    • , Nelson Leung
    •  & Frank Bridoux
  • Viewpoint |

    Here, four leading researchers discuss key considerations related to women's kidney health, including specific risk factors, the main challenges and barriers to care and policies and systems that could be implemented to improve the kidney health of women and their offspring.

    • Gloria E. Ashuntantang
    • , Vesna D. Garovic
    • , Ita P. Heilberg
    •  & Liz Lightstone
  • Review |

    Increasing evidence suggests that renin-expressing cells are involved in a range of physiological processes beyond their traditional role in blood pressure regulation. Here, the authors describe the role of these cells in nephrovascular development, regeneration, oxygen sensing, haematopoiesis and immune responses.

    • R. Ariel Gomez
    •  & Maria Luisa S. Sequeira-Lopez
  • Review |

    The authors present sexual dimorphism at the molecular, cellular and tissue level and suggest that it contributes to differences in disease onset, susceptibility, prevalence and treatment responses in hypertension and cardiovascular disease. Several factors that confer relative cardioprotection in women are discussed, including biological age, sex hormones, sex chromosome complement and lifestyle.

    • Katrina M. Mirabito Colafella
    •  & Kate M. Denton

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