BDNF function in health and disease

Agustin Anastasia and Barbara L. Hempstead

February 2014 Vol 15 No 2

Published online: 27 Dec 2013

Brain-derived neurotrophic factor (BDNF) is the most widely expressed and well-characterized member of the neurotrophin family in the mammalian brain. It is generated following cleavage of the precursor protein proBDNF, and BDNF, proBDNF and the prodomain are all biologically active. Functionally, BDNF has roles in various stages of neural circuit development, and it also regulates neural circuit structure and synaptic plasticity in the adult brain. This Poster summarizes the molecular functions of BDNF in the CNS and highlights its therapeutic potential for conditions such as Alzheimer's disease, Parkinson's disease, stroke and spinal cord injury.
This poster is freely available thanks to support from EVER Neuro Pharma.