News & Comment

  • Comment |

    Brain implants are being trialled for their potential to ameliorate treatment-resistant conditions or to restore function. However, there are no clear guidelines for continued access to brain implants for trial participants whose symptoms improve with these devices.

    • Gabriel Lázaro-Muñoz
    • , Daniel Yoshor
    • , Michael S. Beauchamp
    • , Wayne K. Goodman
    •  & Amy L. McGuire
  • Research Highlight |

    In mice, aggression is regulated by the circadian suprachiasmatic nucleus through at least two neural pathways.

    • Natasha Bray
  • Research Highlight |

    A combination of electrochemical neuromodulation of spinal leg circuits and physical training in a robotic rehabilitation system restored volitional locomotion in rodents with severe spinal cord injury.

    • Sian Lewis
  • Research Highlight |

    Two studies provide insight into the neural circuits integrating competing threat signals, such as pain and hunger.

    • Katherine Whalley
  • Research Highlight |

    A study of post-mortem brains from individuals of difference ages suggests that hippocampal neurogenesis in humans decreases during childhood and is absent in adults.

    • Natasha Bray
  • Research Highlight |

    In the spinal cord and thalamus of mice, astrocyte-generated interleukin-33 instructs microglia to engulf synapses and thus regulates neural circuit development.

    • Darran Yates
  • Research Highlight |

    This study shows that human neural stem cell grafts re-establish a neuronal relay across spinal cord injury in rhesus monkeys.

    • Katharine H. Wrighton
  • Research Highlight |

    Neurons exhibiting synaptic upscaling or downscaling in response to decreases or increases in activity, respectively, show changes in protein expression that depend on the duration and the polarity of the change.

    • Natasha Bray
  • Research Highlight |

    Study employs DNA methylation editing to reactivate FMR1 expression and reverse phenotypic deficits in cells derived from individuals with fragile X syndrome.

    • Katherine Whalley
  • Research Highlight |

    Upregulated bursting activity in the lateral habenula is associated with depression-like behaviours in rats and mice, and depends on NMDA receptors, T-type voltage-sensitive calcium channels and the astrocytic inwardly rectifying potassium channel KIR4.1.

    • Natasha Bray
  • Research Highlight |

    A population of 'anxiety cells' that encode anxiogenic information and drive avoidance behaviour is identified in the mouse hippocampus.

    • Katherine Whalley
  • Research Highlight |

    In mice, consumption of a high-salt diet induces accumulation of T helper 17 lymphocytes in the gut, leading to a rise in plasma interleukin-17 levels as well as neurovascular dysfunction and cognitive deficits.

    • Darran Yates
  • Research Highlight |

    Axons of striatal dopaminergic neurons are shown to release dopamine in a RIM-dependent manner and with a high release probability from axonal active zone-like structures.

    • Sian Lewis
  • Research Highlight |

    Human-gained enhancers (regulatory elements in the human genome that are more active in the human lineage) are shown to regulate progenitor proliferation in the outer subventricular zone, an area that is substantially larger in humans compared with other primates.

    • Sian Lewis
  • Research Highlight |

    Two recent papers reveal that the activity-regulated cytoskeleton-associated proteins ARC and Drosophila melanogaster dArc1 auto-assemble into mRNA-containing, virus-like capsids that are released by neurons in exosomal vesicles and that can be endocytosed at the postsynaptic compartment.

    • Natasha Bray