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Nature Reviews Neuroscience (11 November 2009) | doi:10.1038/nrn2765

Neuroimmunology: Crawling into the brain

Lucy Bird

A study involving real-time imaging of effector T cells provides new insight into how autoreactive T cells interact with cerebral structures and access the central nervous system (CNS) to cause autoimmune disease. Fl|[uuml]|gel and colleagues induced experimental autoimmune encephalomyelitis in rats with intravenous injection of effector T cells specific for the CNS antigen myelin basic protein (MBP).