Table of contents

From the editors

p655 | doi:10.1038/nrn2483


Research Highlights

Affective disorders: Baby blues | PDF (145 KB)

p657 | doi:10.1038/nrn2488

Neuronal polarity: Changing identity | PDF (127 KB)

p658 | doi:10.1038/nrn2476

Sleep: sleepless pressure | PDF (155 KB)

p658 | doi:10.1038/nrn2486

Cortical processing: States of change | PDF (153 KB)

p659 | doi:10.1038/nrn2475

In the news

Motor neurons galore | PDF (100 KB)

p659 | doi:10.1038/nrn2487

Neurodegenerative disease: Prion proteins take a knock | PDF (133 KB)

p660 | doi:10.1038/nrn2481

Axon guidance: Pioneering exit | PDF (157 KB)

p660 | doi:10.1038/nrn2485

In brief

Evolution | Synaptic plasticity | Repair | Auditory system | PDF (115 KB)

p660 | doi:10.1038/nrn2490

Neurogenesis: Newborns reach out | PDF (134 KB)

p661 | doi:10.1038/nrn2479

Development: Knowing your place | PDF (129 KB)

p662 | doi:10.1038/nrn2484

Synaptic plasticity: ARC de LTD | PDF (147 KB)

p663 | doi:10.1038/nrn2482

In brief

Neurological disorders | Neuronal circuits | Development | PDF (127 KB)

p663 | doi:10.1038/nrn2489



Molecular mechanisms of L-DOPA-induced dyskinesia

Peter Jenner

p665 | doi:10.1038/nrn2471

Dyskinesia is a treatment-limiting side effect of dopaminergic replacement therapies in Parkinson's disease. Here Jenner discusses what we know about the molecular causes of dyskinesia induction and expression, highlighting recent findings that suggest that altered glutamatergic transmission might be important.

The genetics of early telencephalon patterning: some assembly required

Jean M. Hébert & Gord Fishell

p678 | doi:10.1038/nrn2463

The genetic interactions that pattern the embryonic telencephalon are highly complex. Fishell and Hébert bring clarity to these events by describing the key genetic interactions that underlie the patterning of the early telencephalon into distinct proliferative zones.

Velocity computation in the primate visual system

David C. Bradley & Manu S. Goyal

p686 | doi:10.1038/nrn2472

The detection of a moving object's velocity by the visual system is thought to require several sequential computational steps. Bradley and Goyal outline current theoretical models that explain how local-velocity estimates are obtained and integrated, and consider the experimental evidence for each model.

Computational models of schizophrenia and dopamine modulation in the prefrontal cortex

Edmund T. Rolls, Marco Loh, Gustavo Deco & Georg Winterer

p696 | doi:10.1038/nrn2462

Computational neuroscience contributes to our understanding of complex diseases. Here, Rolls and colleagues review several models of schizophrenia, focusing on those that include attractor networks. They show how reduced stability of attractor networks in the prefrontal cortex might produce symptoms of schizophrenia.




Using genetic data in cognitive neuroscience: from growing pains to genuine insights

Adam E. Green, Marcus R. Munafò, Colin G. DeYoung, John A. Fossella, Jin Fan & Jeremy R. Gray

p710 | doi:10.1038/nrn2461

Brain activity has been used as an intermediate phenotype that links genetic polymorphisms with cognitive (dys)function. Gray and colleagues discuss how this approach can be refined to ultimately reveal how variations in DNA can lead to changes in cognitive function.


Applications of real-time fMRI

R. Christopher deCharms

p720 | doi:10.1038/nrn2414

The development of real-time fMRI has enabled us to watch our own brain in action 'live'. Christopher deCharms provides an overview of current and potential applications of this technique, including its use as a brain–machine interface and in learned control over brain activation.

Corrigendum: 'Where' and 'what' in the whisker sensorimotor system

p730 | doi:10.1038/nrn2491