Table of contents
September 2008 Vol 9 No 9
From the editors
p655 | doi:10.1038/nrn2483
Research Highlights
Affective disorders: Baby blues | PDF (145 KB)
p657 | doi:10.1038/nrn2488
Neuronal polarity: Changing identity | PDF (127 KB)
p658 | doi:10.1038/nrn2476
Sleep: sleepless pressure | PDF (155 KB)
p658 | doi:10.1038/nrn2486
Cortical processing: States of change | PDF (153 KB)
p659 | doi:10.1038/nrn2475
In the news
Motor neurons galore | PDF (100 KB)
p659 | doi:10.1038/nrn2487
Neurodegenerative disease: Prion proteins take a knock | PDF (133 KB)
p660 | doi:10.1038/nrn2481
Axon guidance: Pioneering exit | PDF (157 KB)
p660 | doi:10.1038/nrn2485
In brief
Evolution | Synaptic plasticity | Repair | Auditory system | PDF (115 KB)
p660 | doi:10.1038/nrn2490
Neurogenesis: Newborns reach out | PDF (134 KB)
p661 | doi:10.1038/nrn2479
Development: Knowing your place | PDF (129 KB)
p662 | doi:10.1038/nrn2484
Synaptic plasticity: ARC de LTD | PDF (147 KB)
p663 | doi:10.1038/nrn2482
In brief
Neurological disorders | Neuronal circuits | Development | PDF (127 KB)
p663 | doi:10.1038/nrn2489
Reviews
Molecular mechanisms of L-DOPA-induced dyskinesia
Peter Jenner
p665 | doi:10.1038/nrn2471
Dyskinesia is a treatment-limiting side effect of dopaminergic replacement therapies in Parkinson's disease. Here Jenner discusses what we know about the molecular causes of dyskinesia induction and expression, highlighting recent findings that suggest that altered glutamatergic transmission might be important.
The genetics of early telencephalon patterning: some assembly required
Jean M. Hébert & Gord Fishell
p678 | doi:10.1038/nrn2463
The genetic interactions that pattern the embryonic telencephalon are highly complex. Fishell and Hébert bring clarity to these events by describing the key genetic interactions that underlie the patterning of the early telencephalon into distinct proliferative zones.
Velocity computation in the primate visual system
David C. Bradley & Manu S. Goyal
p686 | doi:10.1038/nrn2472
The detection of a moving object's velocity by the visual system is thought to require several sequential computational steps. Bradley and Goyal outline current theoretical models that explain how local-velocity estimates are obtained and integrated, and consider the experimental evidence for each model.
Computational models of schizophrenia and dopamine modulation in the prefrontal cortex
Edmund T. Rolls, Marco Loh, Gustavo Deco & Georg Winterer
p696 | doi:10.1038/nrn2462
Computational neuroscience contributes to our understanding of complex diseases. Here, Rolls and colleagues review several models of schizophrenia, focusing on those that include attractor networks. They show how reduced stability of attractor networks in the prefrontal cortex might produce symptoms of schizophrenia.
Perspectives
Opinion
Using genetic data in cognitive neuroscience: from growing pains to genuine insights
Adam E. Green, Marcus R. Munafò, Colin G. DeYoung, John A. Fossella, Jin Fan & Jeremy R. Gray
p710 | doi:10.1038/nrn2461
Brain activity has been used as an intermediate phenotype that links genetic polymorphisms with cognitive (dys)function. Gray and colleagues discuss how this approach can be refined to ultimately reveal how variations in DNA can lead to changes in cognitive function.
Opinion
Applications of real-time fMRI
R. Christopher deCharms
p720 | doi:10.1038/nrn2414
The development of real-time fMRI has enabled us to watch our own brain in action 'live'. Christopher deCharms provides an overview of current and potential applications of this technique, including its use as a brain–machine interface and in learned control over brain activation.
Corrigendum: 'Where' and 'what' in the whisker sensorimotor system
p730 | doi:10.1038/nrn2491
