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Research Highlights
Nature Reviews Neuroscience 9, 663 (1 September 2008) | doi:10.1038/nrn2482
Synaptic plasticity: ARC de LTD
Abstract
Metabotropic glutamate receptor (mGluR)-dependent long-term depression (mGluR-LTD) relies on dendritic protein synthesis that occurs within minutes of mGluR activation, but the identities of the synthesized proteins are largely unknown. Two new studies show that the rapid translation of activity-regulated cytoskeleton-associated protein (ARC; also termed activity-regulated gene of 3.1 kb (ARG3.
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