Table of contents
June 2008 Vol 9 No 6
From the editors
p407 | doi:10.1038/nrn2395
Research Highlights
Addiction: Lasting impressions | PDF (307 KB)
p409 | doi:10.1038/nrn2399
Neuroimaging: Free will? | PDF (197 KB)
p410 | doi:10.1038/nrn2404
Synaptic transmission: Diffusion to speed up recovery | PDF (268 KB)
p410 | doi:10.1038/nrn2407
In the news
Visible improvement | PDF (76 KB)
p410 | doi:10.1038/nrn2409
Learning: Dabbling in babbling | PDF (276 KB)
p411 | doi:10.1038/nrn2405
Neural circuits: Sing a song of "sex please" | PDF (297 KB)
p412 | doi:10.1038/nrn2396
Neurodegenerative disease: Taking stock of grafts | PDF (194 KB)
p412 | doi:10.1038/nrn2397
In brief
Addiction | Axon guidance | Memory | Excitotoxicity | PDF (91 KB)
p412 | doi:10.1038/nrn2413
In brief
Cognitive neuroscience | Neurodegenerative disease | Development | Synaptic plasticity | PDF (113 KB)
p413 | doi:10.1038/nrn2412
Neurodegenerative disease: Inhibiting 
-secretase where it matters | PDF
(338 KB)
p414 | doi:10.1038/nrn2403
Neurogenetics: Understanding deletions | PDF (120 KB)
p414 | doi:10.1038/nrn2406
Neurotransmission: Silence of the synapses | PDF (230 KB)
p415 | doi:10.1038/nrn2408
Progress
A technicolour approach to the connectome
Jeff W. Lichtman, Jean Livet & Joshua R. Sanes
p417 | doi:10.1038/nrn2391
New technologies promise to decipher whole-brain connectivity at a much greater resolution than ever before. Here, Lichtman, Livet and Sanes, the creators of Brainbow, critically assess the applications and challenges of this technology and those of other existing and emerging technologies.
Reviews
Presynaptic glutamate receptors: physiological functions and mechanisms of action
Paulo S. Pinheiro & Christophe Mulle
p423 | doi:10.1038/nrn2379
Our understanding of the functional roles of presynaptic glutamate receptors continues to grow. Pinheiro and Mulle capture the current state of this knowledge, describing the modes and mechanisms of action of these receptors and the evidence for their contributions to synaptic transmission.
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei & Wen-Cheng Xiong
p437 | doi:10.1038/nrn2392
Polymorphisms in the genes that encode neuregulin 1 (NRG1) and its receptor ErbB4 have been associated with schizophrenia. Mei and Xiong review the role of NRG1 signalling in neural development and synaptic plasticity and discuss how alterations in NRG1 signalling might contribute to schizophrenia.
The neural control of micturition
Clare J. Fowler, Derek Griffiths & William C. de Groat
p453 | doi:10.1038/nrn2401
Fowler and colleagues review the pathways and neurotransmitters in the brain, the spinal cord and the peripheral nervous system that regulate the lower urinary tract, and discuss how disruption of the control of micturition leads to incontinence.
The neural systems that mediate human perceptual decision making
Hauke R. Heekeren, Sean Marrett & Leslie G. Ungerleider
p467 | doi:10.1038/nrn2374
Heekeren and colleagues review neurophysiological and neuroimaging studies of monkeys and humans making perceptual decisions, highlighting both the similarities and the differences in their decision-making processes and providing a new model for the neural architecture that underlies perceptual decision making in humans.
Perspective
Opinion
Can the immune system be harnessed to repair the CNS?
Phillip G. Popovich & Erin E. Longbrake
p481 | doi:10.1038/nrn2398
A growing field of neuroscience aims to understand how immune responses can promote CNS repair. Popovich and Longbrake discuss current approaches to manipulate neuroimmune interactions and give their opinion on the challenges ahead.
Corrigendum: Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
Lorenzo A. Cingolani & Yukiko Goda
p494 | doi:10.1038/nrn2410
