Abstract

GABA (-aminobutyric acid) type A receptors (GABA_ARs) mediate most fast synaptic inhibition in the mammalian brain, controlling activity at both the network and the cellular levels. The diverse functions of GABA in the CNS are matched not just by the heterogeneity of GABA_ARs, but also by the complex trafficking mechanisms and protein–protein interactions that generate and maintain an appropriate receptor cell-surface localization. In this Review, we discuss recent progress in our understanding of the dynamic regulation of GABA_AR composition, trafficking to and from the neuronal surface, and lateral movement of receptors between synaptic and extrasynaptic locations. Finally, we highlight a number of neurological disorders, including epilepsy and schizophrenia, in which alterations in GABA_AR trafficking occur.

Author affiliations

1. Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
2. Department of Pharmacology, University College London, London, WC1E 6BT, UK.

Correspondence to: Stephen J. Moss^1,2 Email: sjmoss@mail.med.upenn.edu

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.