Table of contents
From the editors
p159 | doi:10.1038/nrn2350
Research Highlights
Neuronal circuits: Dissecting learning | PDF (524 KB)
p161 | doi:10.1038/nrn2347
Cellular neurobiology: Mitochondria in the dock | PDF (200 KB)
p162 | doi:10.1038/nrn2339
Neurogenetics: Predicting antidepressant response | PDF (290 KB)
p162 | doi:10.1038/nrn2346
Mirror neurons: Singing in the brain | PDF (316 KB)
p163 | doi:10.1038/nrn2340
In the news
Great expectations | PDF (76 KB)
p163 | doi:10.1038/nrn2344
Development: Instructions for the hippocampus | PDF (271 KB)
p164 | doi:10.1038/nrn2341
Signal transduction: New tricks for old JNKs | PDF (372 KB)
p164 | doi:10.1038/nrn2342
In brief
Neurodegenerative disease | Cortical development | Circadian rhythms | PDF (93 KB)
p164 | doi:10.1038/nrn2351
In brief
Neurological disorders | Pain | Sleep | Learning and memory | PDF (96 KB)
p165 | doi:10.1038/nrn2352
Synaptic plasticity: Rise and shine (we are all morning people!) | PDF (188 KB)
p166 | doi:10.1038/nrn2348
Pain: Picking out the pieces of GABA receptors | PDF (286 KB)
p166 | doi:10.1038/nrn2349
Neurodegenerative disease: In the PINK | PDF (370 KB)
p167 | doi:10.1038/nrn2343
Reviews
Neurovascular signalling defects in neurodegeneration
Serena Zacchigna, Diether Lambrechts & Peter Carmeliet
p169 | doi:10.1038/nrn2336
There are many parallels in the mechanisms that underlie the development and function of the vascular and nervous systems. Carmeliet and colleagues describe molecules that have activity on both neural and vascular cells and highlight their roles in neurodegenerative disease.
Article series: Memory systems
The hippocampus and memory: insights from spatial processing
Chris M. Bird & Neil Burgess
p182 | doi:10.1038/nrn2335
Bird and Burgess review the hippocampus's role in memory in light of a model of neuronal processing in which hippocampal activity constrains neocortical information to be perceivable from a single location. This enables spatially coherent mental imagery, explaining several recent findings and theoretical conflicts.
Imaging in vivo: watching the brain in action
Jason N. D. Kerr & Winfried Denk
p195 | doi:10.1038/nrn2338
Advances in cellular imaging have been crucial for improving our understanding of many aspects of neuroscience. Kerr and Denk describe how sophisticated optical imaging techniques allow us to image activity in single neurons or neuron populations in living animals.
Pyramidal neurons: dendritic structure and synaptic integration
Nelson Spruston
p206 | doi:10.1038/nrn2286
The unique dendritic morphology of pyramidal neurons is likely to have an impact on their function. Spruston discusses how the properties of these neurons' distinct dendritic domains might contribute to their integration of synaptic inputs.
The pathophysiological basis of dystonias
Xandra O. Breakefield, Anne J. Blood, Yuqing Li, Mark Hallett, Phyllis I. Hanson & David G. Standaert
p222 | doi:10.1038/nrn2337
Dystonia is characterized by involuntary movements and postures. Breakefield and colleagues provide insight into the underlying neuronal dysfunction through a comprehensive review of the genes that are responsible for primary dystonias, animal models of dystonia and brain imaging of dystonia patients.
Perspective
Science and society
Functional neuroimaging of the vegetative state
Adrian M. Owen & Martin R. Coleman
p235 | doi:10.1038/nrn2330
Functional MRI has shown that aspects of cognitive and emotional processing and even conscious awareness might be retained in some patients who have been diagnosed as vegetative. Owen and Coleman discuss the clinical, legal and scientific implications of these findings.
