Abstract

Higher-order actin-based networks (actin superstructures) are important for growth-cone motility and guidance. Principles for generating, organizing and remodelling actin superstructures have emerged from recent findings in cell-free systems, non-neuronal cells and growth cones. This Review examines how actin superstructures are initiated de novo at the leading-edge membrane and how the spontaneous organization of actin superstructures is driven by ensembles of actin-binding proteins. How the regulation of actin-binding proteins can affect growth-cone turning and axonal regeneration is also discussed.

Author affiliations

1. Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA.
2. Graduate Program in Cell and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA.
3. Molecular, Cellular and Integrative Neuroscience Program, Colorado State University, Fort Collins, Colorado 80523, USA.

Correspondence to: James R. Bamburg³ Email: jbamburg@lamar.colostate.edu

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