Table of contents
October 2008 Vol 9 No 10
From the editors
p731 | doi:10.1038/nrn2511
Research Highlights
Development: Dynein branches out | PDF (157 KB)
p733 | doi:10.1038/nrn2506
Antipsychotics: Tuning muscarinic receptor signalling | PDF (127 KB)
p734 | doi:10.1038/nrn2503
In brief
Molecular neuroscience | Development | Decision making | Neuroanatomy | PDF (123 KB)
p734 | doi:10.1038/nrn2510
Auditory system: Making hairs for hearing | PDF (125 KB)
p735 | doi:10.1038/nrn2496
Chemosensation: Alarm bells | PDF (135 KB)
p735 | doi:10.1038/nrn2504
Epigenetics: Losing control | PDF (153 KB)
p736 | doi:10.1038/nrn2498
Synaptic transmission: On the probability of release | PDF (152 KB)
p736 | doi:10.1038/nrn2500
In the news
A genetic bond? | PDF (102 KB)
p736 | doi:10.1038/nrn2508
In brief
Addiction | Neurodegeneration | Neurogenesis | Sensory systems | PDF (138 KB)
p737 | doi:10.1038/nrn2509
Synaptic development: Safe retreat | PDF (125 KB)
p738 | doi:10.1038/nrn2502
Cortical plasticity: Out with the old | PDF (136 KB)
p738 | doi:10.1038/nrn2507
Learning and memory: Replay that track | PDF (152 KB)
p739 | doi:10.1038/nrn2505
Progress
Research in motion: the enigma of Parkinson's disease pathology spread
Patrik Brundin, Jia-Yi Li, Janice L. Holton, Olle Lindvall & Tamas Revesz
p741 | doi:10.1038/nrn2477
Parkinson's disease is characterized by progressive neurodegeneration, but the underlying mechanisms are unclear. Brundin and colleagues discuss how recent reports on the outcome of neuronal grafts carried out in patients with Parkinson's disease might shed light on the disease's progression.
Reviews
CART peptides: regulators of body weight, reward and other functions
G. Rogge, D. Jones, G. W. Hubert, Y. Lin & M. J. Kuhar
p747 | doi:10.1038/nrn2493
Since their discovery as factors that were upregulated by psychostimulant drugs, CART peptides have emerged as major neurotransmitters and hormones. Here, Kuhar and colleagues provide an overview of the various effects of CART peptides.
The insulin paradox: aging, proteotoxicity and neurodegeneration
Ehud Cohen & Andrew Dillin
p759 | doi:10.1038/nrn2474
Aging is a major risk factor for the development of human neurodegenerative diseases. Here, Cohen and Dillin discuss the roles of insulin/IGF1 signalling in toxic protein aggregation and the links between this pathway and the emergence of late-onset neurodegenerative disease.
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
Lars Bertram & Rudolph E. Tanzi
p768 | doi:10.1038/nrn2494
Studies of the genetic causes of Alzheimer's disease have yielded a bewildering array of candidate genes. Bertram and Tanzi describe the results of ongoing systematic meta-analyses of these studies and discuss how some of the risk factors identified might contribute to disease pathology.
Perspectives
Opinion
High-content analysis in neuroscience
Mike Dragunow
p779 | doi:10.1038/nrn2492
High-content analysis (HCA), the combination of automated microscopy and automated image analysis, has the potential to be a powerful tool for neuroscience research. Mike Dragunow outlines the factors to consider when adopting HCA in an academic setting, and the benefits that researchers can expect.
Opinion
Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms
Robert J. DeRubeis, Greg J. Siegle & Steven D. Hollon
p788 | doi:10.1038/nrn2345
Cognitive therapy and antidepressant medication are both effective treatments for depression. Derubeis and colleagues propose common and divergent neural changes that might underlie the antidepressant effects of both types of treatment and that could explain the enduring, relapse-preventing effects of cognitive therapy.
An interview with Rob DeRubeis for Neuropod is available for download.
