Review
Nature Reviews Neuroscience 9, 36-45 (January 2008) | doi:10.1038/nrn2294
Glucose neurotoxicity
David R. Tomlinson1 & Natalie J. Gardiner1 About the authors
Abstract
Neurons have a constantly high glucose demand, and unlike muscle cells they cannot accommodate episodic glucose uptake under the influence of insulin. Neuronal glucose uptake depends on the extracellular concentration of glucose, and cellular damage can ensue after persistent episodes of hyperglycaemia — a phenomenon referred to as glucose neurotoxicity. This article reviews the pathophysiological manifestation of raised glucose in neurons and how this can explain the major components of diabetic neuropathy.
- View At a Glance
Author affiliations
-
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Email: david.tomlinson@manchester.ac.uk
Email: natalie.gardiner@manchester.ac.uk
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageNature Letters to Editor (13 Apr 2000)
Renal tubular basement membrane and collagen type IV in diabetes mellitusKidney International Original Article
Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat modelKidney International Original Article
See all 25 matches for Research
