Abstract

The spatio-temporal timing of the last round of mitosis, followed by the migration of neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is subdivided into functionally defined cortical areas. Whereas many of the cellular and molecular mechanisms have been established in rodents, there are a number of unique features that require further elucidation in primates. Recent findings both in rodents and in primates indicate that regulation of the cell cycle, specifically of the G1 phase has a crucial role in controlling area-specific rates of neuron production and the generation of cytoarchitectonic maps.

Author affiliations

1. INSERM, U846, 18 Avenue Doyen Lépine, 69675 Bron Cedex, France; Stem Cell and Brain Research Institute, Department of Stem cells and Cortical Development, 69675 Bron Cedex, France; Université de Lyon, Université Lyon 1, 69003 Lyon, France.

Correspondence to: Colette Dehay¹ Email: dehay@lyon.inserm.fr

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