Review
Nature Reviews Neuroscience 8, 128-140 (February 2007) | doi:10.1038/nrn2059
There is a Correspondence and an Author's response (1 July 2008) associated with this article.
Lipid raft microdomains and neurotransmitter signalling
John A. Allen1, Robyn A. Halverson-Tamboli1 & Mark M. Rasenick1,2 About the authors
Abstract
Lipid rafts are specialized structures on the plasma membrane that have an altered lipid composition as well as links to the cytoskeleton. It has been proposed that these structures are membrane domains in which neurotransmitter signalling might occur through a clustering of receptors and components of receptor-activated signalling cascades. The localization of these proteins in lipid rafts, which is affected by the cytoskeleton, also influences the potency and efficacy of neurotransmitter receptors and transporters. The effect of lipid rafts on neurotransmitter signalling has also been implicated in neurological and psychiatric diseases.
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Author affiliations
- Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA.
- Department of Psychiatry and the Program in Neuroscience, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA.
Correspondence to: Mark M. Rasenick1,2 Email: raz@uic.edu
Published online 29 December 2006
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