Review
Nature Reviews Neuroscience 8, 89-100 (February 2007) | doi:10.1038/nrn2058
Spindle regulation in neural precursors of flies and mammals
Joshua J. Buchman1,2 & Li-Huei Tsai1 About the authors
Abstract
The mitotic spindle is the cellular scaffold that facilitates proper segregation of genetic material during cell division. Far from being static, the spindle is a dynamically regulated tool that can alter its size, shape and position during mitosis. Work in both insect and vertebrate systems has shown that regulation of this structure involves an array of highly conserved proteins. Moreover, it is now clear that tight regulation of the spindle during the process of neurogenesis is paramount to proper cell division and generation of the nervous system as a whole.
- View At a Glance
Author affiliations
- Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.
- Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA.
Correspondence to: Li-Huei Tsai1 Email: lhtsai@mit.edu
Published online 17 January 2007
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Numb, neurogenesis and epithelial polarityNature Neuroscience News and Views (01 Jul 2007)
Spindles cotton on to junctions, APC and EB1Nature Cell Biology News and Views (01 Mar 2001)
See all 12 matches for News And ViewsRESEARCH
Control of planar divisions by the G-protein regulator LGN maintains progenitors in the chick neuroepitheliumNature Neuroscience Article (01 Nov 2007)
Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cellsThe EMBO Journal Article (02 Jun 2004)
See all 41 matches for Research
